Method for preparation of disodium pamidronate

Details Method for preparation of disodium pamidronate Method for preparation of disodium pamidronate

1998-12-10

2000-12-12

Vollano, Jean F

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

562 11, C07F 938

Patent

active

061601659

ABSTRACT:
The invention includes a method for the preparation of disodium pamidronate comprising: (a) preparing a stirred slurry of pamidronate in water, (b) adding a solution of sodium hydroxide to give a clear solution at pH of about 6.5, (c) filtering the solution and (d) freezing and lyophilizing the solution to give an amorphous essentially anhydrous disodium pamidronate which contains .ltoreq.2 wt-% water.

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