Method for preparation of crystalline perindopril erbumine

Details Method for preparation of crystalline perindopril erbumine Method for preparation of crystalline perindopril erbumine

2003-10-21

2008-11-25

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S419000

Reexamination Certificate

active

07456296

ABSTRACT:
A process for preparation of crystalline perindopril erbumine of formula (II)which exhibits the X-ray (powder) diffraction pattern like that shown in FIG.2The process comprises reacting a solution of perindopril of formula (I),in a solvent selected from N,N-dimethylformamide, dimethyl acetals of lower aliphatic aldehydes, dimethyl ketals of lower aliphatic ketones and 1,2-dialkoxyethane with tertiary butylamine and crystallization of the erbumine salt thus obtained by heating the reaction mixture to reflux, filtering hot, cooling gradually to 20° C. to 30° C., and further cooling to 0° C. to 15° C. for 30 minutes to 1 hour and finally filtering off and drying the crystals.

REFERENCES:
patent: 4914214 (1990-04-01), Baliarda
patent: 1371659 (2003-12-01), None
patent: WO 01/83439 (2001-11-01), None
patent: WO 01/87835 (2001-11-01), None
patent: WO 01/87836 (2001-11-01), None
Guillory, “Generation of Polyjorphs, Hydrates, Solvates, and Amorphous Solids” in Polymorphism in Pharmaceutical Solids, vol. 95, Marcel Dekker, Inc., p. 183-226.
http://www.m-w.com/dictionary.
http://www.dictionary.reference.com/browse/gradually.

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