Method for preparation of cefuroxime axetil

Details Method for preparation of cefuroxime axetil Method for preparation of cefuroxime axetil

2006-06-20

2006-06-20

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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07064198

ABSTRACT:
A process for preparation of cefuroxime axetil of formula (I) of at least 96% purity and substantially free of analogous Δ2-isomer of formula (II) and other impurities. The process comprisesreacting cefuroxime acid of formula (III)with (R,S)-1-acetoxyethyl bromide of formula (IV),and a Group I or II metal carbonate in the presence of a compound of formula (V),in-line-formulae description="In-line Formulae" end="lead"?MmHnPqOr  (V)in-line-formulae description="In-line Formulae" end="tail"?wherein M is Group I or II metal; m is 1, 2, 3; n is 0, 1, 2, or 4; q is 1 or 2; r is 4, 7 or 8; in the presence of a C1-4alcohol and a polar tertiary amide solvent selected from N,N-dimethylacetamide, N,N-dimethylformamide, N,N-dimetheylpropionamide, N,N-diethylacetamide, N,N-diethylformamide and N,N-diethylpropionamide at a temperature ranging from about −30 to +30° C. and subjecting the product thus obtained to a desired step of purification.

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