Method for preparation of antihemophilic factor

Details Method for preparation of antihemophilic factor Method for preparation of antihemophilic factor

1977-04-14

1978-08-01

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, A23J 106, A61K 3514

Patent

active

041042662

ABSTRACT:
An improved method for preparation of purified AHF is disclosed. The method includes the cryoprecipitation of plasma, followed by a cold extraction of the cryoprecipitate at low temperature, approximately 0.degree. C, to obtain a cold insoluble fraction. The cold insoluble fraction is then extracted at approximately 21.degree. C to obtain an AHF-containing solution. By incorporating a cold extraction step to selectively remove some impurities prior to extraction of AHF from cryoprecipitate, there has been obtained a substantial increase in the purity as well as the potency of AHF without the use of any new precipitant or adsorbent in the system.

REFERENCES:
patent: 3631018 (1971-12-01), Shanbrom et al.
patent: 3652530 (1972-03-01), Johnson et al.
patent: 4025618 (1977-05-01), Garber et al.
Hersshgold et al., J. Lab. Clinical Medicine, vol. 67, No. 1, (Jan.) 1966, pp. 23-32.

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