Method for preparation of an alkaline and aspirin combination co

Details Method for preparation of an alkaline and aspirin combination co Method for preparation of an alkaline and aspirin combination co

1995-11-13

1997-09-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424489, A61K 920

Patent

active

056653883

ABSTRACT:
A method of manufacturing a stabilized, essentially sodium free, granular aspirin compound mixed with a granular potassium bicarbonate compound comprising the steps of determining a desirable dose size of such aspirin compound which is to be packaged. Weighing out an amount of granular aspirin based on the dose size determined. Placing an amount of such granular potassium bicarbonate compound into a container which is uniformly distributed over a bottom surface of such container to a predetermined depth. Placing such container into a heat treating apparatus. Heat treating the granular potassium bicarbonate compound at a temperature which is at least sufficient to convert an outer surface layer of such granular potassium bicarbonate compound to potassium carbonate and for a time which is at least sufficient to ensure that essentially all of such outer surface layer of the granular potassium bicarbonate compound is converted to such potassium carbonate. Weighing out an amount of such heat treated granular potassium bicarbonate compound based on the dose size determined. Placing the granular aspirin into a package and, thereafter, placing such heat treated granular potassium bicarbonate compound into such package thereby forming the stabilized, essentially sodium free, granular aspirin compound mixed with a granular potassium bicarbonate compound.

REFERENCES:
patent: 2985562 (1961-05-01), Millard et al.
patent: 3105792 (1963-10-01), White
patent: 3773922 (1973-11-01), Gergely
patent: 4093710 (1978-06-01), Sass et al.
patent: 4515949 (1985-05-01), Santroch et al.

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