Method for preparation of...

Details Method for preparation of... Method for preparation of...

2006-10-10

2006-10-10

Coleman, Brenda (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07119197

ABSTRACT:
An efficient and high-yielding method for the preparation of optically pure (S)-(+) -10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by resolution of racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide using a tartaric acid anhydride.

REFERENCES:
patent: 5451687 (1995-09-01), Sato et al.
patent: 0751129 (1997-01-01), None
patent: 10087536 (1998-04-01), None
patent: 10139732 (1998-05-01), None
patent: WO97/01742 (1997-01-01), None
Jan Benes et al.: “Anticonvulsant and sodium channel-blocking properties of novel 10, 11-Dihydro-5H-dibenz(b,f)azephine-5-caboxamide derivatives”, J. Med. Chem., Am. Chem. Soc., vol. 42, 1999, pp. 2582-2587, XP002206156.

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