Method for preparation herpes simplex virus subunit vaccine

Details Method for preparation herpes simplex virus subunit vaccine Method for preparation herpes simplex virus subunit vaccine

1985-08-23

1988-02-09

Kepplinger, Esther M.

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435239, 530412, 530826, A61K 3912, C12N 702, C12N 700

Patent

active

047241462

ABSTRACT:
A method for the preparation of an herpes simplex virus subunit vaccine, which comprises subjecting a solution containing glycoproteins gA and gB to column chromatography using, as a gel for chromatography, sulfuric acid ester of cellulose or a crosslinked polysaccharide to adsorb the glycoproteins gA and gB onto the gel in the presence of an anionic surfactant or a nonanionic surfactant, eluting the adsorbed glycoproteins to obtain an eluate containing the glycoproteins, and subjecting the eluate to gel filtration to obtain a filtrate containing the glycoproteins.

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