Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1985-04-22
1987-07-28
Marantz, Sidney
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
435806, 436 63, 436503, 436504, 436906, G01N 3353
Patent
active
046832130
ABSTRACT:
A method for evaluating the fertility of a test male mammal relative to the fertility of a control male mammal. The method includes the steps of collecting samples of semen from the test male and the control male. The binding affinity of a selected glycosaminoglycan to the sperm of the semen samples is measured by a selected means for measuring binding affinities. The fertility of the test male may be evaluated as higher or lower than that of the control male by the degree to which the binding affinity of the glycosaminoglycan to its sperm is higher or lower than the binding affinity of the glycosaminoglycan to the sperm of the control male.
REFERENCES:
N. A. C. Cressie and D. D. Keightley, (1979), "The Underlying Structure of the Direct Linear Plot With Application to the Analysis of Hormone-Receptor Interactions", J. Steroid Biochem., 11, 1173.
D. Rodbard, (1976), "Estimation of Molecular Weight by Gel Filtration and Gel Electrophoresis, II. Statistical and Computational Considerations", Methods of Protein Separation, vol. 2, N. Catsimpoolas, ed. (Plenum Press, NY), Ch. 4.
J. M. Bedford (1970), "Sperm Capacitation and Fertilization in Mammals", Biol. Reprod., Supp. 2, 128-158.
S. Aonuma, et al., (1973), "Studies on Sperm Capacitation: I. The Relationship Between a Guinea Pig Sperm Coating Antigen and a Sperm Capacitation Phenomenon", Reprod. Fertil., 35 425-432.
D. W. Fawcett, (1975), "The Mammalian Spermatozoon", Dev., Bio., 44, 394-436.
R. Yanagimachi, (1978), "Sperm--Egg Association in Mammals", Curr. Top. Dev. Biol., 12, 83-105.
C. N. Lee, R. W. Lenz, and R. L. Ax (1983), "Bovine Sperm Undergo Capacitation when Exposed to Glycosaminoglycans In Vitro", 75th Ann. Mtng. Soc. Anim. Sci., Abstract 530.
R. W. Lenz, M. E. Bellin, and R. L. Ax, (1983), "Rabbit Spermatozoa Undergo an Acrosome Reaction in the Presence of Glycosaminoglycans", Gamete Res., 8, 11.
H. G. Grimek and R. L. Ax, (1982), "Chromatographic Comparison of Chondroitin-Containing Proteoglycan from Small and Large Bovine Ovarian Follicles", Biochem. Biophys. Res. and Comm., 104, 1401.
C. N. Lee and R. L. Ax (1984), "Concentrations and Composition of Glycosaminoglycans in the Female Bovine Reproductive Tract", J. Dairy Sci., G7, 2006-2009.
R. L. Ax, K. Dickson, and R. W. Lenz, (1985), "Induction of the Acrosome Reaction in Response to Chondroitin Sulfates In Vitro is Related to Non-Return Rates of Dairy Bulls", J. Dairy Sci., 68, 387-390.
N. N. Delgado, et al. (1982), "Heparin Binding Sites in the Human Spermatozoa Membrane", Arch. Androl., 8, 87.
R. R. Handrow, et al. (1984), "Specific Binding of the Glycosaminoglycan .sup.3 H-Heparin to Bull, Monkey, and Rabbit Spermatozoa In Vitro", J. Androl., 5, 51.
G. H. Barlow (1983), "Molecular Weight Distribution Determination on Heparin Samples", Thromb. Res., 31, 513.
L. Kjellen, et al., (1977), "Binding of Heparin and Heparan Sulfate to Rat Liver Cells", Biochem. Biophys. Res. Comm., 74, 126.
C. Labarca and K. Paigen, (1980), "A Simple, Rapid, and Sensitive DNA Assay Procedure", Anal. Biochem., 102, 344.
Houser David J.
Marantz Sidney
Saunders David A.
Wisconsin Alumni Research Foundation
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