Method for predicting the effectiveness of antineoplastic therap

Details Method for predicting the effectiveness of antineoplastic therap Method for predicting the effectiveness of antineoplastic therap

1994-08-10

1995-06-27

Fleisher, Mindy B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 436813, C12Q 168, C07H 2102, A61K 4300, A61K 4900

Patent

active

054279160

ABSTRACT:
The effectiveness of selected antineoplastic agents may be determined in individual patients by comparing the level of expression of one or more selected growth-regulated genes in neoplastic cells taken from the patient before and shortly after the initiation of therapy. A decrement in expression is prognostic of eventual remission, while a lack of decrement indicates that remission is unlikely. The test may also be accomplished by comparing the level of expression of growth-regulated genes in neoplastic cells in culture before and after incubation of the cells with the selected antineoplastic agents.

REFERENCES:
Tonini et al., Cancer Research 47, 4544-4547 (Sep. 1, 1987).
Calabretta et al., Proc. Natl. Acad. Sci. USA 82, 4463-4467 (Jul. 1985).
Kelly et al., Cell 35, 603-610 (Dec. 1983).
Preisler et al., J. Cell. Biochem., Suppl. 11A, Abstract #D510, p. 237 (1987).
Preisler et al., Cancer Res. 47:874-880 (1987).

Affiliated with

Also associated with

Rating

Method for predicting the effectiveness of antineoplastic therap does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for predicting the effectiveness of antineoplastic therap, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for predicting the effectiveness of antineoplastic therap will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-286491