Method for predicting responsiveness to a pharmaceutical...

Chemistry: analytical and immunological testing – Lipids – triglycerides – cholesterol – or lipoproteins

Reexamination Certificate

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C436S063000, C514S007400, C424S009200

Reexamination Certificate

active

08084261

ABSTRACT:
Methods for using TRL V6 as a biomarker for the modulation of triglyceride and/or lipoprotein metabolism in a mammal induced by a weight loss pharmaceutical agent. The biomarker may be used for determining if an individual patient will likely respond favorably to a given weight loss pharmaceutical agent.

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patent: 0051054 (2000-08-01), None
patent: 2007039184 (2007-12-01), None
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Karpe, et al, “Differences in Postprandial Concentrations of Very-Low-Density Lipoprotein and Chylomicron Remnants Between Normotriglyceridemic and Hypertriglyceridemic Mem With and Without Coronary Heart Disease”; Metabolism, vol. 48, No. 3 Mar. 1999; pp. 301-307.
Otvos, et al., “NMR Lipoprotein Subclass Analysis: NMR LipoProfile Research Service Description”—Research and Development Division, James Otvos, Ph.D.,Chief Scientific Officer.
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Suter, et al., “Effect of orlistat on postprandial lipemia, NMR lipoprotein subclass profiles and particle size”, Atherosclerosis, 180, 2005, pp. 127-135.

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