Method for precipitating natural avermectins

Details Method for precipitating natural avermectins Method for precipitating natural avermectins

1997-07-10

1999-05-18

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 76, 435119, 435123, 435886, C12N1/20

Patent

active

059050349

ABSTRACT:
A process for separating a natural B avermectin from a natural avermectin containing fermentation broth by using an aqueous precipitation. The process comprises extracting natural avermectins from the fermentation broth with a water miscible solvent and adding sufficient water to precipitate the natural B avermetins. Preferably, the water miscible solvent is a C.sub.1 -C.sub.3 alcohol, acetone, or acetonitrile. In addition, an acid, base, salt or surfactant may be added to facilitate the precipitation. This invention provides an isolation technique that substitutes the use of an aqueous precipitation for nonaqueous solvent precipitations. The reduction in use of nonaqueous solvents provides economic, environmental and safety benefits.

REFERENCES:
patent: 5206155 (1993-04-01), Omura et al.
patent: 5234831 (1993-08-01), Hafner et al.
Schulman et al. Antimicrob. Agents Chemother. vol. 31(5), pp. 744-747, 1987 .

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