Method for PR-39 peptide regulated stimulation of angiogenesis

Details Method for PR-39 peptide regulated stimulation of angiogenesis Method for PR-39 peptide regulated stimulation of angiogenesis

2008-03-18

2008-03-18

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07345021

ABSTRACT:
The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF-1α and a consequential stimulation of angiogenesis in-situ.

REFERENCES:
patent: 5654273 (1997-08-01), Gallo et al.
patent: 5830993 (1998-11-01), Blecha et al.
patent: 6133233 (2000-10-01), Ross et al.
patent: 7202212 (2007-04-01), Simons et al.
patent: 7202217 (2007-04-01), Simons et al.
Gerads et al.,Cell Mol. Life Sci. 54:253-262 (1998).
Gerads et al.,J. Mol.Biol. 275:113-121 (1998).
Baumeister et al.,Cell 92:367-380 (1998).

Affiliated with

Also associated with

Rating

Method for PR-39 peptide regulated stimulation of angiogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for PR-39 peptide regulated stimulation of angiogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for PR-39 peptide regulated stimulation of angiogenesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2789583