Method for PR-39 peptide mediated selective inhibition of...

Details Method for PR-39 peptide mediated selective inhibition of... Method for PR-39 peptide mediated selective inhibition of...

2007-01-30

2007-01-30

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C514S002600, C514S012200, C514S015800

Reexamination Certificate

active

09474967

ABSTRACT:
The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IκBα and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with IκBα is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of IκBα, a decrease of NFκB activity, and a down-regulation of NFκB-dependent gene expression.

REFERENCES:
patent: 6133233 (2000-10-01), Ross et al.

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