Chemistry: analytical and immunological testing – Phosphorus containing – Organic
Reexamination Certificate
2005-04-05
2005-04-05
Gakh, Yelena G. (Department: 1743)
Chemistry: analytical and immunological testing
Phosphorus containing
Organic
C436S103000, C436S173000, C436S086000
Reexamination Certificate
active
06875618
ABSTRACT:
A method of detecting and measuring phosphorus in samples is disclosed. The measurement of phosphorylation is made with an inductively coupled plasma mass spectrometer (ICP-MS), coupled to a reactive collision cell. The reactive collision cell is employed to ensure interference-free detection of phosphorus ions, by the formation of product ions with a different mass to charge ratio. Accurate measurement of phosphorylation in samples is important in proteomics.
REFERENCES:
patent: 6140638 (2000-10-01), Tanner et al.
Wind et al. “Analysis of Protein Phosphorylation by Capillary Liquid Chromatography Coupled to Element Mass Spectrometry with 31P Detection and to Electrospray Mass Spectrometry”, Analytical Chemistry (2001), 73(1), 29-35.*
Resing et al. (1995) Mass Spectrometric Analysis of 21 Phosphorylation Sites in the Internal Repeat of Rat Profilaggrin, Precursor of an Intermediate Filament Associated Protein,Biochemistry34: 9477-9487.
Tanner et al. (1999) A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). II. Reduction of Interferences Produced Within the Cell,J. Am. Soc. Mass Spectrom.10: 1083-1094.
Wind et al. (2001) Protein Phosphorylation Degree: Determination by Capillary Liquid Chromotography and Inductively Coupled Plasma Mass Spectrometry,Anal. Chem.73: 3006-3010.
Bandura Dmitry R.
Baranov Vladimir I.
Tanner Scott D.
Gakh Yelena G.
MDS Inc.
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