Chemistry: physical processes – Physical processes – Crystallization
Reexamination Certificate
2005-10-04
2005-10-04
Silverman, Stanley S. (Department: 1754)
Chemistry: physical processes
Physical processes
Crystallization
C117S014000, C436S086000, C436S174000
Reexamination Certificate
active
06951575
ABSTRACT:
A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.
REFERENCES:
patent: 4263010 (1981-04-01), Randolph
patent: 4668584 (1987-05-01), Uzgiris et al.
patent: 4755363 (1988-07-01), Fujita et al.
patent: 4833233 (1989-05-01), Carter
patent: 4886646 (1989-12-01), Carter et al.
patent: 4900147 (1990-02-01), Brolwey et al.
patent: 4909933 (1990-03-01), Carter et al.
patent: 4919899 (1990-04-01), Herrmann et al.
patent: 5009861 (1991-04-01), Plass-Link
patent: 5013531 (1991-05-01), Snyder et al.
patent: 5076698 (1991-12-01), Smith et al.
patent: 5078975 (1992-01-01), Rhodes et al.
patent: 5096676 (1992-03-01), McPherson et al.
patent: 5106592 (1992-04-01), Stapelmann et al.
patent: 5124935 (1992-06-01), Wallner et al.
patent: 5193685 (1993-03-01), Trevithick
patent: 5221410 (1993-06-01), Kushner et al.
patent: 5256241 (1993-10-01), Noever
patent: 5419278 (1995-05-01), Carter
patent: 5544254 (1996-08-01), Hartley et al.
patent: 5581476 (1996-12-01), Osslund
patent: 5641681 (1997-06-01), Carter
patent: 5643540 (1997-07-01), Carter et al.
patent: 5790421 (1998-08-01), Osslund
patent: 5855753 (1999-01-01), Trau et al.
patent: 5872010 (1999-02-01), Karger et al.
patent: 5873394 (1999-02-01), Meltzer
patent: 5973779 (1999-10-01), Ansari et al.
patent: 5985356 (1999-11-01), Schultz et al.
patent: 5997636 (1999-12-01), Gamarnik et al.
patent: 6036920 (2000-03-01), Pantoliano et al.
patent: 6039804 (2000-03-01), Kim et al.
patent: 6057159 (2000-05-01), Lepre
patent: 6069934 (2000-05-01), Verman et al.
patent: 6148878 (2000-11-01), Ganz et al.
patent: 6268158 (2001-07-01), Pantoliano et al.
patent: 6297021 (2001-10-01), Nienaber et al.
patent: 6303322 (2001-10-01), Pontoliano et al.
patent: 6360792 (2002-03-01), Ganz et al.
patent: 6402837 (2002-06-01), Shtrahman et al.
patent: 6404849 (2002-06-01), Olson et al.
patent: 6417007 (2002-07-01), Gittleman et al.
patent: 6558623 (2003-05-01), Ganz et al.
patent: 6579358 (2003-06-01), DeLucas et al.
patent: 6592824 (2003-07-01), DeLucas et al.
patent: 2001/0006807 (2001-07-01), Bray et al.
patent: 2001/0016191 (2001-08-01), Osslund
patent: 2001/0016314 (2001-08-01), Anderson et al.
patent: 2001/0019845 (2001-09-01), Bienert et al.
patent: 2001/0027745 (2001-10-01), Weigl et al.
patent: 2001/0032582 (2001-10-01), DeTitta et al.
patent: 2001/0055669 (2001-12-01), Schultz et al.
patent: 2001/0055775 (2001-12-01), Schultz et al.
patent: 2002/0022250 (2002-02-01), Hendrickson et al.
patent: 2002/0029814 (2002-03-01), Unger et al.
patent: 2002/0048610 (2002-04-01), Cima et al.
patent: 2002/0054663 (2002-05-01), Olson et al.
patent: 2002/0062783 (2002-05-01), Bray
patent: 2002/0064485 (2002-05-01), DeLucas et al.
patent: 2002/0067800 (2002-06-01), Newman et al.
patent: 2002/0106318 (2002-08-01), DeLucas et al.
patent: 2002/0110816 (2002-08-01), Santarsiero et al.
patent: 2002/0143153 (2002-10-01), Santarsiero et al.
patent: 2002/0144738 (2002-10-01), Unger et al.
patent: 2002/0155504 (2002-10-01), Santarsiero et al.
patent: 2002/0160426 (2002-10-01), Santarsiero et al.
patent: 2002/0164812 (2002-11-01), DeLucas
patent: 2002/0169512 (2002-11-01), Stewart
patent: 2002/0173052 (2002-11-01), Santarsiero et al.
patent: 2002/0182637 (2002-12-01), Santarsiero et al.
patent: 2003/0000597 (2003-01-01), Ganz et al.
patent: 2003/0022383 (2003-01-01), DeLucas
patent: 2003/0022384 (2003-01-01), DeLucas
patent: 2003/0027348 (2003-02-01), DeLucas et al.
patent: 2003/0027997 (2003-02-01), Bray et al.
patent: 2003/0096421 (2003-05-01), DeLucas et al.
patent: 0 553 539 (1993-04-01), None
patent: 02001013054 (2001-01-01), None
patent: WO 99/04361 (1999-01-01), None
patent: WO 00/60345 (2000-12-01), None
patent: WO 01/92293 (2001-12-01), None
patent: WO 02/093139 (2002-11-01), None
patent: WO 01/26797 (2003-04-01), None
patent: WO 01/26797 (2003-04-01), None
Stewart, P.D.S. et al., “Practical Experimental Design Techniques for Automatic and Manual Protein Crystallization” J Crystal Growth 196, pp. 665-673.
Baldock, P. et al., “A Comparison of Microbatch And Vapor Diffusion For Initial Screening of Crystallization Conditions” J. Crystal Growth 168; pp. 170-174.
Cudney, B. et al., “Screening and Optimization Strategies For Macromolecular Crystal Growth”, Acta Crystallogr D50, pp. 414-423.
McPherson, A., “Two Approaches to the Rapid Screening of Crystallization Conditions”J Crystal Growth 122; pp. 161-167.
Ward, K.B. et al., “Automating Crystallization Experimients. In: Crystallization of Nucleic Acids and Proteins: a Practical Approach” eds. A. Ducruix & R. Giege, Oxford University Press, New York; pp. 291-310.
Weber, P.C., “Overview of Protein Crystallization Methods” Methods Enzymol, 276, pp. 13-22 (1997).
McPherson, A. “Crystallization of Biological Marcromolecules” Cold Spring Harbor Laboratory Press; (1999).
McPherson, A. “Crystallization of Macromolecules: general principals” Methods Enzymol, 114; pp. 112-120 (1985).
McPherson, A. “Use of Polyethylene Glycol in the Crystallization of Macromolecules” Methods Enzymol; 114; pp. 120-125 (1985).
McPherson, A. “Crystallization of Proteins by Variation of pH or Temperature”, Methods Enzymol, 114; pp. 125-127.
Jancarik, J. et al., “Sparse Matrix Sampling: A Screening Method For Crystallization of Proteins”, J. Appl. Cryst. 24; pp. 409-411 (1991).
Gilliland , G.L. et al., “Biological Macromolecule Crystallization Database, Version 3.0: New Features, Data and the NASA Archive for Protein Crystal Growth Data” Acta Crystallogr. D50; pp. 408-413 (1994).
Perrakis, A et al., Protein Microcrystals and the Design of a Micro-Diffractometer: Current Experience and Plans at EMBL and ESRF/ID13; Acta Crystallogr D55; pp. 1765-1770 (1999).
Pebay-Peyroula, R. et al., “X-ray Structure of Bacteriorhodopsin at 2.5 Angstroms from Microcrystals Grown Lipidic Cubic Phases” SCIENCE 277; pp. 1676-1681.
Sibille, L., Clunie, J.C., Baird, J.K. Solvent evaporation rates in the closed capillary vapor diffusion method of protein crystal growth.J. Cryst. Growth110, 80-88 (1991).
Montelione, G, Anderson, S: Structural genomics: keystone for a human proteome project.Nature Struct Biol(1999) 6(1):11-12.
Burley, SK, Almo, SC, Bonanno, JB, Capel, M, Chance, MR, Gaasterland, T, Lin, D, Sali, A, Studier, FW, Swaminathan, S: Structural genomics: beyond the Human Genome Project.Nature Genet(1999) 23:151-157.
Gaasterland, T: Structural genomics: Bioinformatics in the driver's seat.Nature Biotechnol(1998) 16:625-627.
Rost, B: Marrying structure and genomics.Structure(1998) 6:259-263.
Shapiro, L, Lima, CD: The Argonne Structural Genomics Workshop: Lamaze class for the birth of a new science.Structure(1998) 6:265-267.
Ducruix, A, Giege, R (Eds):Crystallization of nucleic acids and proteins. A practical approach. Second edition.Oxford: Oxford University Press; (1999).
D-Arcy, A: Crystallizing proteins—a rational approach?Acta Crystallogr D(1994) 50:469-471.
Stura, EA, Satterthwait, AC, Calvo, JC, Kaslow, DC, Wilson, IA: Reverse screening.Acta Crystallogr D(1994) 50:448-455.
Hampton Research Homepage on World Wide Web at URL: http://www.hamptonresearch.com.
Emerald BioStructures Homepage on World Wide Web at URL: http://www.emeraldbiostructures.com.
Carter, C, Jr: Efficient factorial designs and the analysis of macromolecular crystal growth conditions.Methods(1990) 1(1):12-24.
Carter, C, Jr: Design of crystallization experiments and
Cornell Earl W.
Jaklevic Joseph M.
Nordmeyer Robert A.
Santarsiero Bernard D.
Schultz Peter G.
Medina Maribel
Peters Howard M.
Peters Verny Jones Schmitt & Aston, LLP
Silverman Stanley S.
The Regents of the University of California
LandOfFree
Method for performing high density submicroliter... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for performing high density submicroliter..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for performing high density submicroliter... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3442389