Method for percutaneously administering physiologically active a

Details Method for percutaneously administering physiologically active a Method for percutaneously administering physiologically active a

1985-05-31

1987-12-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514947, A61K 3155

Patent

active

047104970

ABSTRACT:
A method of percutaneously administering a physiologically active agent which comprises applying to the skin of a mammal a physiologically active agent in a carrier system which comprises at least one adjuvant and at least one solvent. The adjuvant can be selected from aliphatic hydrocarbons, halogen substituted aliphatic hydrocarbons, alcohol esters of aliphatic carboxylic acids, mono- or di-ethers, ketones, or mixtures thereof. The solvent can be selected from thioglycerols, lactic acid and esters thereof, cyclic ureas, compounds represented by the general formula R.sub.1 R.sub.2 NCONR.sub.3 R.sub.4, pyrrolidone-type compounds, amides, lactones or mixtures thereof.

REFERENCES:
patent: 4038417 (1977-07-01), Nelson
patent: 4039664 (1977-08-01), Stoughton et al.
patent: 4232006 (1980-11-01), Taplin et al.
Lachman et al--"The Theory & Practice of Industrial Pharmacy", 2nd ed., pp. 217-220, 1976.
Merck Index, 9th ed., 1976, p. 684 (#5075).

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