Method for percutaneous delivery of ibuprofen using hydroalcohol

Details Method for percutaneous delivery of ibuprofen using hydroalcohol Method for percutaneous delivery of ibuprofen using hydroalcohol

1990-01-24

1992-03-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424444, 424488, 514944, A61K 914

Patent

active

050931334

ABSTRACT:
An ibuprofen containing hydroalcoholic gel of pH 3.5 to 6.0 for topically treating inflammation or pain comprising an effective amount of ibuprofen; 40 to 60% alcohol, e.g. ethanol or isopropyl alcohol; 0-20% of a non-volatile solvent, e.g. propylene glycol; 2.0 to 5.0% gelling agents, e.g. 2.5% hydroxypropyl cellulose or 4.0% polyacrylic acid polymer; sufficient base, e.g. triethanolamine, to adjust the pH to between 3.5 and 6.0; and water; methods for delivering ibuprofen through the skin to treat inflammation or pain using the hydroalcoholic gel; and use of substantially pure S-ibuprofen to topically treat such inflammation or pain.

REFERENCES:
patent: 4185100 (1980-01-01), Rovee
patent: 4533546 (1985-08-01), Kishi
patent: 4849418 (1989-07-01), Lohner et al.
patent: 4877620 (1989-10-01), Loew et al.
S. S. Adams, Ph.D., P. Bresloff, Ph.D. and C. G. Mason, Ph.D., "The Optical Isomers of Ibuprofen", Current Medical Research and Opinion, vol. 3, No. 8, p. 552, (1975).
S. S. Adams, P. Bresloff, C. G. Mason, "Pharmacological Differences Between the Optical Isomers of Ibuprofen: Evidence for Metabolic Inversion of the (-)-Isomer", J. Pharm. Pharmac., vol. 28, p. 256, (1976).
E. J. D. Lee, K. Williams, R. Day, G. Graham and D. Champion, "Stereoselective Disposition of Ibuprofen Enantiomers in Man", Br. J. Clin., Pharmac., vol. 19, pp. 669-679, (1985).
K. M. Williams and R. O. Day, "Stereoselective Disposition--Basis for Variability in Response to NSAID's", Birkhauser Verlag, Basel, pp. 119-126, (1985).

Affiliated with

Also associated with

Rating

Method for percutaneous delivery of ibuprofen using hydroalcohol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for percutaneous delivery of ibuprofen using hydroalcohol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for percutaneous delivery of ibuprofen using hydroalcohol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-271008