Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1997-05-19
1998-07-07
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530338, 530344, A61K 3800, C07K 100
Patent
active
057770760
ABSTRACT:
acid as the starting compound. The compound is separated into N.sub.2, R'OH and N-carboxyanhydride of formula (II). ##STR1## The compound (II) together with an amino acid or peptide with at least one free .alpha.-amino function is introduced into a reactive medium to obtain a dipeptide or a higher peptide than the added peptide.
REFERENCES:
T. Machinami et al., "Potential Antitumor N-Carbamoyl-N'-methyl-N-40 -nitroso Derivatives of Amino Acids", pp. 1333-1334, Bulletin of the Chemical Society of Japan, vol. 48, No. 4, 1975.
Wei-ci Tang et al., Synthesis of Potentially Antineoplastic Derivatives of Pharm. (Weinheim), 314, 1981.
K. Ehresmann et al., "Syntheses of Potentially Antineoplastic Amides and II.sup.5) ",pp. 481-487, Arch. Pharm. (Weinheim), 317, Jun. 1984.
G. Eisenbrand et al., "Synthesis and Characterization of Steroid-linked N-(2-Chloroethyl) nitrosoureas", pp. 863-872, Arch. Pharm. (Weinheim), 322, 1989.
Inouye et al J.C.S. Perkins I (1977) pp. 1905-1915.
Benefice Sylvie
Bied Catherine
Calas Patrick
Choukroun Henri
Collet Helene
Celsa Bennett
Hill Jr. Robert J.
Universite Montpellier II Sciences et Techniques du Languedoc
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