Liquid purification or separation – With means to add treating material – Chromatography
Patent
1990-01-31
1991-01-15
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
210635, 210657, 55 67, 55386, 141 12, 141 34, 141 73, 141 80, B01D 1508
Patent
active
049851438
ABSTRACT:
Column chromatography beds are packed through the application of static force. A slurry of the chromatography bed material and a non-viscous liquid is filled into the column plugged at one end, and allowed to settle. The column is transferred to a centrifuge, and centrifuged for a brief period of time to achieve a predetermined packing level, at a range generally of 100-5,000 gravities. Thereafter, the plug is removed, other fixtures may be secured, and the liquid is allowed to flow out through the bed. This results in an evenly packed bed, with no channeling or preferential flow characteristics.
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Mikes' Laboratory Handbook of Chromatographic and Allied Methods, John Wiley & Sons Inc., New York, 1979, p. 354.
Angeles Rosalie M.
Freeman David H.
Keller Suzanne
The University of Maryland
Therkorn Ernest G.
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