Method for oxidatively consuming volatile sulfur compounds at bo

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424 45, 424 49, 424 52, 424 53, 424 57, 424 7802, 424427, 424434, 424437, 424430, 424661, 424673, 424676, 424DIG15, 514944, 514945, 514966, 514967, 514968, A61K 900, A61K 3300

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058340033

ABSTRACT:
A method for oxidatively consuming volatile sulfur compounds selected from the group consisting of dimethylsulfide, hydrogen sulfide, and methylmercaptan at the epithelial barrier of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices to maintain the epithelial barrier and reduce penetration of any of Candida, Actinobacillus actinomycetumcomitans, Pseudomonades, and Porphyromonas gingivalis, said method comprising the step of applying to the orifices a composition comprising a topical preparation selected from the group consisting of liquid solutions, suspensions, semi-solids, salves, creams, and suppositories, wherein the topical preparation contains chlorine dioxide in a concentration in the range of about 0.005% to about 2.0% and a phosphate compound selected from the group consisting of disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodiuit phosphate, or sodium monofluorophosphate in a concentration in the range of about 0.02% to about 3.0% to retard escape of chlorine dioxide from the composition at a pH in the range of about 6.0 to about 7.4.

REFERENCES:
patent: 3271242 (1966-09-01), McNicholas
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R.J. Genco, T.E. Van Dyke, M.J. Levine, R.D. Nelson and M.E. Wilson, "Molecular Factors Influencing Defects in Periodontal Disease", 1985 Kreshover Lecture, J. Dent. Res., vol. 65, No. 12, Dec. 1986, pp. 1379-1380.
Federal Register, vol. 47, No. 101, Tuesday, May 25, 1982, "Proposed Rules", p. 22801.
J. Tonzetich, "Production and Origin of Oral Malodor: A Review of Mechanisms and Methods of Analysis", J. Periodontol, vol. 48, No. 1, Jan. 1977, pp. 13-20.
Anthony A. Rizzo, "The Possible Role of Hydrogen Sulfide in Human Periodontal Disease", Periodontics, vol. 5, No. 5, Sep./Oct. 1967, pp. 233, 235, 236.
Maria C. Solis-Gaffar, Thomas J. Fischer and Abdul Gaffar, "Instrumental Evaluation of Odor Produced by Specific Oral Microorganisms", J. Soc. Cosmet. Chem., vol. 30, Jul./Aug. 1979, pp. 241-247.

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