Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2007-01-23
2007-01-23
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S252300, C435S069100, C435S101000
Reexamination Certificate
active
10388390
ABSTRACT:
The present invention is directed to methods for producing and selecting novel mutant strains ofB. fragilisthat constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains ofB. fragilisthat constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
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Comstock Laurie E.
Coyne Michael J.
Kasper Dennis L.
Tzianabos Arthur O.
Weinacht Katja G.
Prouty Rebecca E.
Raghu Ganapathirama
The Brigham and Women's Hospital, Inc.
Wolf Greenfield & Sacks P.C.
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