Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1993-09-07
1998-09-22
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
4242371, 4242561, 424497, 424810, 42840221, 42820224, 514885, 514888, 514963, A61K 952, A61K 39085, A61K 3912, A61K 3939
Patent
active
058111280
ABSTRACT:
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immunity.
REFERENCES:
patent: 2738303 (1956-03-01), Blythe
patent: 3474777 (1969-10-01), Figge et al.
patent: 3823228 (1974-07-01), Ferris
patent: 3887699 (1975-06-01), Yolles
patent: 3959457 (1976-05-01), Speaker et al.
patent: 4021364 (1977-05-01), Speiser et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4123519 (1978-10-01), Tribble et al.
patent: 4148876 (1979-04-01), Almeida et al.
patent: 4152413 (1979-05-01), Goodnow
patent: 4152414 (1979-05-01), Harris et al.
patent: 4152415 (1979-05-01), Harris et al.
patent: 4166800 (1979-09-01), Fong
patent: 4196188 (1980-04-01), Besins
patent: 4203968 (1980-05-01), Harris et al.
patent: 4209507 (1980-06-01), Ogino et al.
patent: 4269821 (1981-05-01), Kreuter et al.
patent: 4291016 (1981-09-01), Nougaret
patent: 4292298 (1981-09-01), Davis
patent: 4298002 (1981-11-01), Ronel et al.
patent: 4309405 (1982-01-01), Guley et al.
patent: 4309406 (1982-01-01), Guley et al.
patent: 4326524 (1982-04-01), Drake, Jr. et al.
patent: 4349530 (1982-09-01), Royer
patent: 4367217 (1983-01-01), Gruber et al.
patent: 4384975 (1983-05-01), Fong
patent: 4389330 (1983-06-01), Tice et al.
patent: 4428925 (1984-01-01), Keith
patent: 4428926 (1984-01-01), Keith
patent: 4434153 (1984-02-01), Urquhart et al.
patent: 4439199 (1984-03-01), Amkraut et al.
patent: 4455142 (1984-06-01), Martins et al.
patent: 4479911 (1984-10-01), Fong
patent: 4484923 (1984-11-01), Amkraut et al.
patent: 4524060 (1985-06-01), Mughal et al.
patent: 4525339 (1985-06-01), Behl et al.
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4542025 (1985-09-01), Tice et al.
patent: 4559303 (1985-12-01), Aotani et al.
patent: 4585651 (1986-04-01), Beck et al.
patent: 4590170 (1986-05-01), Akiyoshi et al.
patent: 4610870 (1986-09-01), Jain et al.
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4650769 (1987-03-01), Kakimi et al.
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4681752 (1987-07-01), Melillo
patent: 4690682 (1987-09-01), Lim
patent: 4732763 (1988-03-01), Beck et al.
patent: 4764359 (1988-08-01), Lemelson
patent: 4783336 (1988-11-01), Margel et al.
patent: 4845042 (1989-07-01), Newman et al.
patent: 4919929 (1990-04-01), Beck
patent: 4925673 (1990-05-01), Steiner et al.
patent: 4990336 (1991-02-01), Silvestri et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5126147 (1992-06-01), Silvestri et al.
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5417986 (1995-05-01), Reid et al.
patent: 5503841 (1996-04-01), Doyle et al.
M.F.L.eFevre et al., "Intestinal Barrier to Large Particulates in Mice", Journal of Toxicology and Environmental Health, 6:691-704 (1980).
D.S. Cox et al.:"Oral Induction of the Secretory Antibody Response by Soluble and Particulate Antigens", Int. Arch. Allergy Appl. Immun. 75:126-131 (1984).
Z. Moldoveany et al., "Oral Immunization with Influenza Virus in Biodegradable Microsphres", The Journal of Infectious Diseases 1993; 167:001-007.
D.T. O'Hagan et al., "Absorption of Peptides and Proteins from the Respiratory Tract and the Potential for Development of Locally Administered Vaccine," Critical Reviews Therapeutic Drug Carrier Systems, vol. 7(1):35-97 (1990).
D.T. O'Hagan, "Intestinal Translocation of Particulates-Implications for Drug and Antigen Delivery," Advanced Drug Delivery Reviews, 5:265-285 (1990).
G.R. Ostroff et al., "Macrophage-Targeted Polysaccharide Microcapsules for Antigen and Drug Delivery," Am. Chem. Soc., Div. Polym. Chem., 31(2):200-201 (1990).
Yasuhiko Tabata et al., "Phagocytois of Polymer Microspheres by Macrophages," Advances in Polymer Science 94, pp. 107-141 (1990).
E.G. Langenback et al., "Supramicron-sized Particle Clearance from Alveoli: Rpute and Kinetics," American Physiological Society, pp. 1302-1308 (1990).
W. Sass et al., "Rapid Insorption of Small Particles in the Gut," The American Journal of Gastroenterology, vol. 85(3):255-260 (1990).
Robert H. Gundel, et al., "Antigen-Coated Sepharose Beads Induce Airway Eosinophilia and Airway Hyperresponsiveness in Cynomolgus Monkeys," Am. Rev. Respir. Dis., 140:629-633 (1989).
Per Artursson et al., "Biochemical and Cellular Effects of Degraded Starch Microspheres on Macrophages," International Journal of Pharmaceutics, 52:183-190 (1989).
M. Svartengren et al., "Human Lung Deposition of Particles Suspended in Air or in Helium/Oxygen Mixture," Experimental Lung Research, 15:575-585 (1989).
G.M. Barratt et al., "Delivery of MDP-L-alanyl-cholesterol to Macrophages: Comparison of Liposomes and nanocapsules," The Cancer Journal, vol. 2:439-443 (Nov./Dec. 1989).
D.T. O'Hagan et al., "Poly(butyl-2-cyanoacrylate) Particles as Adjuvants for Oral Immunization," Vaccine, vol. 7:213-215 (Jun. 1989).
B.E. Lehnert et al., "Leukocytic Responses to the Intrapleural Depostion of Particles, Particle-Cell Associations, and the Clearance of Particles From the Pleural Space Compartment," Journal of Toxicology and Enviromental Health, 24:41-66 (1988).
Motoko Kanke et al., "Interaction of Microspheres with Blood Constituents. III. Macrophage Phagocytosis of Various Types of Polymeric Drug Carriers," Research Article, vol. 42(5):157-165 (Sep./Oct. 1988).
Yasuhiko Tabata et al., "Macrophage Phagocytosis of Biodegradable Micropheres Composed of L-lactic Acid/Glycolic Acid homo-and Copolymers," Journal of Biomedical materials Research, vol. 22:837-585 (1988).
Christiane Damge et al., "New Approach for Oral Administration of Insuin with Polyalkylcyanocrylate Nanocapsules as Drug Carrier," Diabetes, vol. 37:246-251 (Feb. 1988).
L. Illum et al., "Bioadhesive Micropheres as a Potential Nasal Drug Delivery System," International Journal of Pharmaceutics, 39:189-199 (1987).
T Harmia et al., "Nanoparticles as Drug Carriers in Ophthalmology," Pharm. Acta Helv., 62(12):322-331 (1987).
Yasuhiko Tabata et al., "Activation of Macrophage In Vitro to Acquire Antitumor Activity by a Muramyl Dipeptide Derivative Encapsulated in Micropheres Composed of Lactide Copolymer," Journal of Controlled Release, vol. 6:189-204 (1987).
Keiko Nishimura et al., "Effect of Multiporous Microspheres Derived from Chitin and Partially Deacetylated Chitin on the Activation of Mouse Peritoneal Macrophages," Vaccine, vol. 5:136-140 (Jun. 1987).
Yashuhiko Tabata et al., "Macrophage Activation Through Phagocytosis of Muramyl Dipeptide Encapsulated in Gelatin Microspheres," J. Pharm. Pharmacol., 39(9):699-703 (1987).
M. Kanke et al., "Interaction of Microspheres with Blood Constituents II: Uptake of Biodegradable Particles by Macrophages," Journal of Parenter Science & Technology, vol. 40(4):114-118 (Jul./Aug. 1986).
Per Artursson et al., "Biodegradable Micropheres II: Immune Response to a Heterologous and an Autologous Protein Entrapped in Polyacryl Starch Microparticles," The Journal of Pharmacology and Experimental Therapeutics, vol. 234(1):255-260 (1985).
J.O. Hill et al., "Cell-Mediated Immunity to Soluble and Particulate Inhaled Antigens," Clin. Exp. Immunol., 38:332-341 (1979).
Kanke et al., "Interaction of Micropheres with Blod Constituents and the Effect on Immune Response," Expo-Congr. Int. Technol. Pharm. 3rd. 4:162-169 (1983).
M.E. LeFevre et al., "Accumulation of Latex in Peyer's Patches and its Subsequent Appereance in Villi and Mesenteric Lymph Nodes," Proceedings of the Society for Experimental Biology and Medicine, 159:298-302 (1978).
Artursson et al., Journal of Pharmaceutical Science, 73:1507, 1984.
Chang, Journal of Bioengineering, 1:25, 1976.
O'Hagan, Palin & Davis, Critical Reviews in Therapeutic Drug Carrier Systems, 4:197, 1978.
Read, et al., Critical Reviews in Therapeutic Drug Carrier Systems, 4:221, 1987.
Harmsen et al., Science, 230:1277, 1985.
Klipste
Eldridge John H.
Gilley Richard M.
Staas Jay K.
Tice Thomas R.
Lovering Richard D.
Southern Research Institute
The UAB Research Foundation
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