Chemistry: analytical and immunological testing – Optical result – With fluorescence or luminescence
Patent
1990-05-22
1992-01-07
Lacey, David L.
Chemistry: analytical and immunological testing
Optical result
With fluorescence or luminescence
436174, 356 36, 435 6, 250261R, G01N 2176
Patent
active
050791699
ABSTRACT:
Method and apparatus for manipulating a microscopic particle by single-beam gradient optical trapping, using an optical beam whose trapping force is substantially independent of position within a view field. The apparatus may be used to extend a polymer filament, and to fix the extended filament at a selected stretching force. When applied to nucleic acid filament, the method may be employed for genomic DNA mapping of filaments up to several megabasepairs in size. The method may also be used for studying the interaction of enzymes or ribosomes with extended DNA in real time.
REFERENCES:
patent: 3710279 (1969-12-01), Ashkin
patent: 3808432 (1972-08-01), Ashkin
patent: 3808550 (1974-04-01), Ashkin
patent: 4327288 (1982-04-01), Ashkin et al.
patent: 4818681 (1989-04-01), Dattagupta
patent: 4893886 (1990-01-01), Ashkin et al.
patent: 4897444 (1990-01-01), Brynes et al.
patent: 4939360 (1990-07-01), Sakai
Optical trapping, cells manipulation and robotics, Neagley et al., 1/1989.
Ashkin, A., "Applications of Laser Radiation Pressure," Science, vol. 210, No. 4474 (1980).
Ashkin, A., "Acceleration and Trapping of Particles by Radiation Pressure," Phys. Rev. Lett., vol. 24, No. 4 (1970).
Ashkin, A. "Trapping of Atoms by Resonance Radiation Pressure," Phys. Rev. Lett., vol. 40, No. 12 (1978).
Ashkin, A. et al., "Optical Trapping and Manipulation of Viruses and Bacteria," Science, 235:1517 (3/87).
Ashkin, A. et al., "Observation of Radiation-Pressure Trapping of Particles by Alternating Light Beams," 54:12 (3/85).
Ashkin, A. et al., "Optical Levitation by Radiation Pressure," App. Phys. Lett., 19:8 (10/71).
Ashkin, A. et al., "Observation of light scattering from nonspherical particles using optical levitation," App. Optics, 19:5 (3/80).
Ashkin, A. et al., "Optical Trapping and Manipulation of Single Living Cells Using Infra-Red Laser Beams", Ber Bunsenges Phys. Chem., 93:254-260 (1989).
Ashkin, A. et al., "Internal cell manipulation using infrared laser traps", Proc. Natl. Acad. Sci. USA, 86:7914-7918 (10/89).
Ashkin, A. et al., "Observation of a single-bead gradient force optical trap for dielectric particles," Optics letters, 11:288 (5/86).
Ashkin, A. et al., "Optical trapping and manipulation of single cells using infrared laser beams," Nature, 330:24/31 (12/87).
Ashkin, A. et al., "Stability of radiation-pressure particle traps: an optical Earnshaw theorem," Optics Letters, 8:10 (10/83).
Berns et al., "Use of a laser-induced optical force trap to study chromosome movement of the mitotic spindle," Proc. Natl. Acad. Sci. USA, 86:4539-5453 (6/89).
Bjorkholm, J. E. et al., "Observation of Focusing of Neutral Atoms by the Dipole Forces of Resonance-Radiation Pressure," Phys. Rev. Lett., 41:20 (11/78).
Block, S. M. et al., "Compliance of bacterial flagella measured with optical tweezers," Nature, 338:6215 (4/89).
Bussery, B. et al., "Potential Energy Curves and Vibration-Rotation . . .," J. Molec. Spectro, 113:21-27 (1985).
Chu, S. et al., "Experimental Observation of Optically Trapped Atoms," Phys. Rev. Lett., 57:3 (7/86).
Dunlap, D. D. et al., "Images of single-stranded nucleic acids by scanning tunnelling microscopy," Nature, vol. 342 (11/89).
Smith, S. B. et al., "Observation of Individual DNA Molecules Undergoing Gel Electrophoresis," Science, 243:203 (1/89).
Pool, R., "Laser-Cooled Atoms Hit Record Low Temperature," Science, 241:1041 (8/88).
Tadir, Y. et al., "Micromanipulation of sperm by a laser generated optical trap," Fertility and Sterility, 52:5 (11/89).
Tadir, Y. et al., "Force generated by human sperm correlated . . .," Fertility and Sterility, 53:5 (5/90).
Wilchek, M., "The Avidin-Biotin Complex in Bioanalytical Applications," Analytical Biochemistry 171:1-32 (1988).
Williams, C. C., "Microscopy of chemical-potential variations on an atomic scale," Nature, vol. 344 (3/90).
Chu Steven
Kron Stephen J.
Dehlinger Peter J.
Edwards Newton
Lacey David L.
The Regents of the Stanford Leland Junior University
LandOfFree
Method for optically manipulating polymer filaments does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for optically manipulating polymer filaments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for optically manipulating polymer filaments will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-821970