Method for optical resolution of 2-(4-chlorophenyl)-3-methylbuta

Details Method for optical resolution of 2-(4-chlorophenyl)-3-methylbuta Method for optical resolution of 2-(4-chlorophenyl)-3-methylbuta

1982-02-01

1983-03-08

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, 562496, C07B 1900

Patent

active

043762131

ABSTRACT:
A method for optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid, which comprises crystallizing out the salt between (+) or (-)-2-(4-chlorophenyl)-3-methylbutanoic acid and diethylamine in a molar proportion of 2:1 predominantly from a super-saturated solution of the salt of 2-(4-chlorophenyl)-3-methylbutanoic acid with diethylamine, collecting the crystallized salt and decomposing the collected salt under acidic conditions to obtain the corresponding optically active acid.

REFERENCES:
patent: 3405159 (1968-10-01), Krieger et al.
patent: 3450751 (1969-06-01), Noyori et al.
patent: 4230860 (1980-10-01), Raghu
patent: 4245116 (1981-01-01), Ohno et al.

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