Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2008-05-06
2008-05-06
Chin, Christopher L. (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
C422S051000, C422S082050, C422S082090, C435S288700, C435S808000, C436S171000, C436S524000, C436S525000, C436S805000, C436S807000
Reexamination Certificate
active
07368294
ABSTRACT:
Method for detecting biological or chemical components in liquid or gas is based on measuring changes of the sensor layer thickness due to binding reactions. A plate or a gap with two surfaces of a solid optical material is used as the sensor layer. The surfaces are located at a distance of more than 10 μm, which allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of ultra bright superluminescent diodes as light sources, because it allows recording within their narrow spectrum a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher sensitivity of the method as compared with thin-film methods.
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Gorshkov Boris Georgievich
Nikitin Petr Ivanovich
Chin Christopher L.
Ladas & Parry LLP
Petr Ivanovich Nikitin
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