Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-04-28
1997-07-08
Wilson, James
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2672, 536 2674, 536 268, 536 276, 536 278, 536 2781, 536 281, 536 285, 536 2853, 536 2854, 544242, 544264, 544265, 544269, 544294, 544296, 544302, 544327, C07H 1906, C07H 1916
Patent
active
056462697
ABSTRACT:
The present invention is directed to improved methods to synthesize oligonucleotide analogs having an acetal linkage, such as a 3',5'-formacetal (3' --O--CH.sub.2 --O-- 5'), 3',5'-thioformacetal (3' --S--CH.sub.2 --O-- 5') or an analogous 2',5' linkage between adjacent nucleoside analog residues. Compositions comprising 5', 3' and 2' phosphinate nucleoside analogs useful in the methods are also provided.
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Matteucci Mark D.
Zhang Jiancun
Gilead Sciences, Inc.
Muenchau Daryl D.
Wilson James
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