Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-06-12
1998-08-11
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 231, C12Q 168, C12N 1511
Patent
active
057926131
ABSTRACT:
RNA molecules are selected from a random sequence library for their ability to bind to a selecting nucleic acid structural element. Selection of RNA aptamers with extensive Watson-Crick complementarity to the nucleic acid ligand is precluded by inclusion of a blocking oligodeoxynucleotide in the binding phase of the selection protocol.
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Cho Bongrae
Nicholas, Jr. Hugh B.
Schmidt Francis J.
LeGuyader John L.
The Curators of the University of Missouri
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