Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-06-14
2011-06-14
Ketter, James S (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S455000, C435S383000
Reexamination Certificate
active
07960103
ABSTRACT:
The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone obtained in step a) during numerous generations under conditions allowing selection for a higher and stable proliferation rate; c) isolation of descendant clones within the cultivated population of step b) still bearing the alteration of step a).
REFERENCES:
patent: 5310667 (1994-05-01), Eichholtz et al.
patent: 00/34433 (2000-06-01), None
Vulic, Marin, et al., “Mutation, recombination, and incipient speciation of bacteria in the laboratory,” Proc. Natl. Acad. Sci., vol. 96, Jun. 1999, pp. 7348-7351.
Mazel, Didier, et al., “Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation,” The EMBO Journal, vol. 13, No. 4, 1994, pp. 914-923.
Marliere Philippe
Mazel Didier
Mutzel Rupert
Centre National de la Recherche Scientifique
Evologic SA
Institut Pasteur
Ketter James S
Mutzel Rupert
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