Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1990-06-25
1993-11-16
Lacey, David L.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524025, 530399, C12N 508, C07K 1514
Patent
active
052623190
ABSTRACT:
The present invention provides (1) an antibody which (a) specifically binds to human TGF-.beta.3 and (b) exhibits substantially no cross reactivity with TGF-.beta.1 or TGF-.beta.2 and (2) antibodies directed against the pro region of the TGF-.beta. precursor. Further, this invention provides a pharmaceutical composition comprising the pro region of the TGF-.beta. precursor. Also, this invention provides methods for diagnosing, detecting and treating subjects suffering from disorders associated with TGF-.beta.3.
REFERENCES:
Roberts et al., "Type B Transforming Growth Factor: A Bifunctional Regulator of Cellular Growth," Proc. Natl. Acad. Sci. USA 82:119-123, Jan. 1985.
Lemoli et al., "TGF-beta 3 Protects Normal Human Hematopoietic Progenitor Cells Treated with 4-Hydroxyperoxycyclophosphamide in vitro," Exp. Hematol. 20(11):1252-1256, 1992.
Dijke Peter T.
Foulkes J. Gordon
Haley John D.
Iwata Kenneth K.
Budens Robert D.
Lacey David L.
Oncogene Science, Inc.
White John P.
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