Method for obtaining antigen-specific Tr1 regulatory...

Details Method for obtaining antigen-specific Tr1 regulatory... Method for obtaining antigen-specific Tr1 regulatory...

2002-05-10

2011-12-13

Juedes, Amy (Department: 1644)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C435S373000, C435S377000

Reexamination Certificate

active

08076133

ABSTRACT:
The invention relates to a method for preparing antigen-specific Tr1 regulatory lymphocytes. The inventive method involves the use of artificial antigen-presenting cells expressing a molecule from the HLA class II system and a human LFA-3 molecule and expressing none of the B7-1, B7-2, B7-H1, CD40, CD23, or ICAM-1 costimulatory molecules.

REFERENCES:
patent: 6355479 (2002-03-01), Webb et al.
patent: 6670146 (2003-12-01), Barrat et al.
patent: WO 97/29183 (1997-08-01), None
patent: WO 97/42324 (1997-11-01), None
patent: WO 9746256 (1997-12-01), None
Wakkach et al., Sep. 2001, J. Immunol. vol. 167: 3107-3113.
Groux et al., 1997, Nature, vol. 389: 737-742.
Bullens et al., Feb. 2001, Int. Immunol. vol. 13: 181-191.
Latouche et al., 2000, Nat. Biotech. vol. 18: 405-409.
Jonuleit, H. et al., Induction of Interleukin 10-producing, Nonproliferating CD4+T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells, Nov. 6, 2000; pp. 1213-1222, J. Exp. Med. , vol. 192, No. 9.
J. Vingerhoets, et al. “Superantigen Activation of CD4+ and CD8+T Cells From HIV-infected Subjects: Role of Costimulatory Molecules and Antigen-Presenting Cells (APC).”Clinical and Experimental Immunology. vol. 111, No. 1, 1998, pp. 12-19. XP002194073.
Hervé Groux, et al. “A CD4+ T-cell Subset Inhibits Antigen-Specific T-cell Responses and Prevents Colitis.”Nature, MacMillian Journals Ltd., London, vol. 389, No. 6652, 1997, pp. 737-742. XP002164695.

Affiliated with

Also associated with

Rating

Method for obtaining antigen-specific Tr1 regulatory... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for obtaining antigen-specific Tr1 regulatory..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for obtaining antigen-specific Tr1 regulatory... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4307532