Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1989-02-21
1991-01-01
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
A61K 3578
Patent
active
049816888
ABSTRACT:
The present invention relates to a novel method for obtaining an extract of Ginkgo biloba leaves.
In the method according to the invention, the following successive operations are performed: grinding of the Ginkgo biloba leaves; extraction of the ground preparation of Ginkgo biloba leaves using an aqueous ketone solvent; concentration of the extraction liquors in order to precipitate the biflavonoids and the hydrophobic substances; filtration of the aqueous concentrate; alkalinization of the filtrate so as to precipitate the proanthocyanidins; removal by filtration of the insoluble fraction containing the proanthocyanidins; acidification of the filtrate; liquid-liquid extraction of the filtrate with a C.sub.4 -C.sub.6 ketone in the presence of ammonium sulfate; and recovery of the extract by taking the ketone phase to dryness.
REFERENCES:
patent: 4564477 (1986-01-01), Takigawa et al.
patent: 4683140 (1987-07-01), Kang
patent: 4734280 (1988-03-01), Braquet
Chemical Abstracts, vol. 101, (1984), p. 306, No. 60122e.
Chemical Abstracts, vol. 107, (1987), p. 324, No. 28395j.
Nakanishi, "The Ginkgolides", Pure and Applied Chemistry, 14, pp. 89-113 (1983).
Okabe, et al., "Ginkgolides", J. Chem. Soc. (C), pp. 2201-2206, (1967).
Ayroles Georges
Cadiou Michel
Rossard Rene-Marc
Pierre Fabre Medicament
Rollins John W.
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