Method for nucleic acid hybridization using back and forth...

Details Method for nucleic acid hybridization using back and forth... Method for nucleic acid hybridization using back and forth...

2008-03-18

2008-03-18

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

Reexamination Certificate

active

10916504

ABSTRACT:
A method and apparatus designed for nucleic acid hybridization employs a hydrogen bond denaturation area with a higher temperature and a lower temperature nucleic acid hybridization area that is immobilized with nucleic acid probes. Nucleic acid-containing samples are introduced into the hydrogen bond denaturation area for heating curled nucleic acids in samples so that they become linear and are guided into the nucleic acid hybridization area. In this area, the nucleic acid hybridization rate can be multiplied by increasing the kinetic energy by the repeated flow of driven fluid. The nucleic acid hybridization apparatus provided by the invention contains a hydrogen bond denaturation area, a nucleic acid hybridization area, a two-way driving apparatus, and a temperature control element. The temperatures in the hydrogen bond denaturation area and the nucleic acid hybridization area can be maintained through the management of this temperature control element, and the fluid can gain needed kinetic energy through the two-way driving pump.

REFERENCES:
patent: 6197595 (2001-03-01), Anderson et al.
patent: 6235471 (2001-05-01), Knapp et al.
patent: 6306598 (2001-10-01), Charych et al.
patent: 6767706 (2004-07-01), Quake et al.

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