Surgery – Miscellaneous – Methods
Patent
1996-07-30
1999-04-06
Yu, Mickey
Surgery
Miscellaneous
Methods
600547, A61B 1900
Patent
active
058904891
ABSTRACT:
Method for non-invasively determining glucose level in fluid of subject, typically blood glucose level. A particular device is mounted on the skin of the patient for a fixed period of time. The device is mounted on the skin such that a substrate such as paper or gel or an aqueous glucose solution carried by the device are in contact with the patient's skin. Water and/or glucose migrates between the substrate or the aqueous glucose solution of the device. The degree of migration of the substance in question is monitored, for example the amount of glucose remaining in an aqueous solution of the device is measured at the end of the fixed period. This can be done by a conventional or other spectrophotometric method, for example. The glucose level is determined based on the degree of migration of the migrating substance. That is, the degree of migration is correlated with previously determined fluid glucose levels based on directly measured fluid glucose levels. In another approach, impedance alone is measured at the skin surface over a relatively short time period, even less than one second and the impedance is correlated with previously determined glucose levels. It is thus possible, through such a correlation, to routinely non-invasively determine fluid glucose levels.
REFERENCES:
patent: 2812757 (1957-11-01), Lusk et al.
patent: 4178916 (1979-12-01), McNamara
patent: 4365637 (1982-12-01), Johnson
patent: 4746508 (1988-05-01), Carey et al.
patent: 4966158 (1990-10-01), Homma et al.
patent: 5036861 (1991-08-01), Sembrowich et al.
patent: 5115133 (1992-05-01), Knudson
patent: 5139023 (1992-08-01), Stanley et al.
patent: 5140985 (1992-08-01), Schroeder et al.
patent: 5146091 (1992-09-01), Knudson
patent: 5179951 (1993-01-01), Knudson
patent: 5222496 (1993-06-01), Clarke et al.
patent: 5433197 (1995-07-01), Stark
P. Lonnroth et al., "A Microdialysis Method Allowing Characterization of Intercellular Water Space in Humans", Am. Physiol. Soc. 253 (Endocrinol. Metab. 16):E228 (1987).
K.M. Halprin et al., "Glucose Entry into the Human Epidermis: II. The Penetration of Glucose into the Human Epidermis In Virto", J. Invest. Derm. 49(6):561 (1967).
H.R. Elden, "The Diffusion of Sodium Chloride, Hydrochloric Acid, and Copper Sulfate Through Glycerol-Water Mixtures" Doctoral Dissertation, The Catholic University of America Press, Washington, D.C., pp. 19-22 (1956).
Zamzow et al.: "Development and evaluation of a wearable blood glucose monitor", ASAIO Transactions 36(3):588-591, Toronto, Canada, 1990.
Dermal Therapy (Barbados) Inc.
O'Hara Kelly
Yu Mickey
LandOfFree
Method for non-invasive determination of glucose in body fluids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for non-invasive determination of glucose in body fluids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for non-invasive determination of glucose in body fluids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1362665