Method for neural stem cell differentiation using valproate

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S029000, C435S352000, C435S363000

Reexamination Certificate

active

07132286

ABSTRACT:
The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural stem cell with a valproate compound or analog thereof.

REFERENCES:
patent: 5672746 (1997-09-01), Nau et al.
patent: 5753506 (1998-05-01), Johe et al.
patent: 5766948 (1998-06-01), Gage et al.
patent: 5851832 (1998-12-01), Weiss et al.
patent: 6103530 (2000-08-01), Carpenter et al.
patent: 6149902 (2000-11-01), Artavanis-Tsakonas et al.
Barker et al. Neural transplantation therapies for Parkinson's and Huntington's diseases. Drug Discov Today. Jun. 1, 2001;6(11):575-582.
Freeman et al. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol. Sep. 1995;38(3):379-88.
Isacson O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurol. Jul. 2003;2(7):417-24.
Kordower et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med. Apr. 27, 1995;332(17):1118-24.
Lindvall et al. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med. Jul. 2004;10 Suppl:S42-50.
Neophytides et al. Sodium valproate in the treatment of cerebellar disorders. Can J Neurol Sci. Nov. 1979;6(4):455-7.
Nutt et al. Treatment of Parkinson's disease with sodium valproate: clinical, pharmacological, and biochemical observations. Can J Neurol Sci. Aug. 1979;6(3):337-43.
Pearce et. al Valproate sodium in Huntington chorea. Arch Neurol. May 1977;34(5):308-9.
Price et al. Sodium valproate in the treatment of levodopa-induced dyskinesia. J Neurol Neurosurg Psychiatry. Aug. 1978;41(8):702-6.
Symington et al. Sodium valproate in Huntington's disease. Am J Psychiatry. Mar. 1978;135(3):352-4.
Weissman IL. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science. Feb. 25, 2000;287(5457):1442-6.
Widner et al. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) N Engl J Med. Nov. 26, 1992;327(22):1556-63.
Tariot et al. Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: Results of a double-blind, placebo-controlled trial. Current Therapeutics Research (2001), 62(1), 51-67.
Mattson MP. Stem cells as therapeutics for neurodegenerative disorders? Exp. Rev. Neurotherap. (2001), 1(2), 267-273.
Herrmann N. Pharmacotherapy for Alzheimer's disease and other dementias. Curr. Opin. Psychiatry (2002), 15:403-409.
Mosby's GenRx (1998) Drug Information “Valproate Sodium” and “Valproic Acid”, Mosby, Baltimore, pp. II-2164-II-2171.
Cinatl et al. Antitumor activity of sodium valproate in cultures of human neuroblastoma cells. Anticancer Drugs. Sep. 1996;7(7):766-73.
Regan et al. In vitro screening for anitconvulsant-induced teratogenesis in neural primary cultures and cell lines. Int. J. Neurosci. 1990; 8(2):143-150.
Loo et al. Differentiation of serum-free mouse embryo cells into astrocytes is accompanied by induction of glutamine synthetase activity. J Neurosci Res. Oct. 1, 1995;42(2):184-91.
Lukaszewicz et al. Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells. J Neurosci. Aug. 1, 2002;22(15):6610-22.
Vescovi et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp Neurol. Mar. 1999;156(1):71-83.
Shetty and Turner, J Neurobiol. 1998;35:395-425.
Skladchikova et al., Neurotoxicol. 1998;19:357-70.
Cinatl et al., Anticancer Drugs 1996;7:766-73.
Slesinger and Singer, Epilepsia 1987; 28:214-21.
Knupfer et al., Anticancer Res 1998; 21:347-51.
Yuan et al, J Biol Chem 2001; 276:31674-83.
Gottlicher et al., Embo J 1998; 20:6969-78.
Manji et al., Biol Psychiatry 2000;48:740-54.
Regan et al., Brain Res 1985; 347:394-98.
Werling et all, Mol Pharmacol 2001; 59:1269-76.
Ourednik et al., “Neural Stem Cells—A Versatile Tool for Cell Replacement and Gene Therapy in the Central Nervous System,”Clin Genet., Oct. 1999, vol. 56, No. 4, pp. 267-278.
Abe, :Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against Ischemic Brain Injury,J. Cereb. Blood Flow Metab., Oct. 2000, vol. 20, No. 10, pp. 1393-1408.
Sanchez-Ramos, et al., “Adult Bone Marrow Stromal Cells Differentiate Into Neural CellsIn Vitro,” Exp. Neurol., Aug. 2000, vol. 164, No. 2, pp. 247-256.
Himelhoch, et al., “Extreme Mood Lability Associated With Systemic Lupus Erythematosus and Stroke Successfully Treated With Valproic Acid,”J Clin Psychopharmacol, Dec. 1996, vol. 16, No. 6, pp. 469-470.
Wallce, “Myoclonus and Epilepsy in Childhood: A Review of Treatment With Valproate, Ethosuximide, Lamotrigine and Zonisamide,”Epilepsy Res., Jan. 1998, vol. 29, No. 2, pp. 147-154.
Kahn et al., “Effect of Sodium Valproate in Three Patients With Organic Brain Syndromes,”Am. J. Psychiatry, Aug. 1988, vol. 145, No. 8, pp. 1010-1011.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for neural stem cell differentiation using valproate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for neural stem cell differentiation using valproate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for neural stem cell differentiation using valproate will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3696555

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.