Method for monitoring the performance of an amino acid sequencer

Details Method for monitoring the performance of an amino acid sequencer Method for monitoring the performance of an amino acid sequencer

1995-02-06

1996-12-31

Alexander, Lyle A.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

436 86, G01N 3348

Patent

active

055893970

ABSTRACT:
The present invention further provides novel synthetic control peptides containing from about 3 to 100 natural amino acid residues that are designed for use in monitoring the proper operation of amino acid sequencers and to monitor peptide or protein cleavage reactions. The control peptide, or mixture of control peptides, are designed to obtain data for many or all common, uncommon and difficult to measure amino acids within 15 sequencer cycles and to provide cleavage sites for at least 4 different amino acid cleavage reactants.

REFERENCES:
patent: 4693993 (1987-09-01), Stewart
Spatola Chem & Biochem of Amino Acids, Peptides and Proteins pp. 267-357, 1983.
"STN Publication" From a Manual Published by STN International, Chem Abstracts Service, Columbus, Ohio.
BIOSIS 94:266097.
BIOSIS 93:339070.
Product Bulletin, "FMOC Multiple Antigenic Peptide (MAP) Resins", Applied Biosystems (1992).
James Bausch et al., "Automated Protein Microsequencing: Using an Amino Acid Homopolymer as an Internal Standard", Biopharm (1989).
Michael W. Hunkapiller, "PTH Amino Acid Analysis", Applied Biosystems, Inc., 14:1-27 (Nov. 18, 1985).

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