Method for monitoring the efficacy of a Mycobacterium avium...

Details Method for monitoring the efficacy of a Mycobacterium avium... Method for monitoring the efficacy of a Mycobacterium avium...

2011-03-08

2011-03-08

Swartz, Rodney P. (Department: 1645)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C424S009100, C424S009200, C424S248100

Reexamination Certificate

active

07902350

ABSTRACT:
The present invention relates toMycobacterium aviumsubspecies paratuberculosis (MAP) as the etiological agent of IBD, including ulcerative colitis and Crohn's disease, as well as Multiple Sclerosis and Alzheimer's Disease. As such, methods for monitoring efficacy of a anti-MAP therapy and determining whether a blood sample is suitable for transfusion are provided based upon presence, absence or amount of MAP nucleic acid.

REFERENCES:
patent: 2003/0175725 (2003-09-01), Kapur et al.
patent: 2003/0228642 (2003-12-01), Shafran
Greenstein et al., “On the action of methotrexate and 6-mercaptopurine onM. aviumsubspeciesparatuberculosis”, PloS ONE 2007 2(1):e161 pp. 1-5.
Greenstein et al., “On the action of 5-amino-salicylic acid and sulfapyridine onM. aviumincluding subspeciesparatuberculosis”, PloS ONE 2007 6:e516 pp. 1-5.
Mishina et al., “On the etiology of Crohn disease”, Proc. Natl. Acad. Sci. USA 1996 93:9816-9820.
Millar et al., “IS900 PCR to detectMycobacterium paratuberculosisin retail supplies of whole pasteurized cows' milk in England and Wales”, Applied and Environmental Microbiology 1996 62(9):3446-3452.

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