Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-04-15
2008-04-15
Foley, Shannon (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C436S064000
Reexamination Certificate
active
10491523
ABSTRACT:
The present invention provides a method for diagnosis, monitoring and prognosticating the disease course of gastrointestinal tumors, comprising determining the level of a cyclin dependent kinase inhibitor (CK1) in a sample and diagnosing the disease and/or recurrence of the disease or prognosticating the disease course from the level of said CK1 in the examined tumor cells. Furthermore the present invention provides a method for tailoring a suitable therapy for gastrointestinal tumors. Another aspect of the present invention are test kits for research and diagnostic purposes.
REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: 5965360 (1999-10-01), Zain et al.
patent: 6033847 (2000-03-01), Sherr et al.
patent: 6316208 (2001-11-01), Roberts et al.
patent: 2003/0157482 (2003-08-01), Keesee et al.
patent: WO99/04238 (1999-01-01), None
Tsujie et al., Oncology, vol. 58, p. 126-136, 2000.
Myung et al., Cancer Letters, vol. 153, p. 129-136, 2000.
He et al., World J of Gastroenterol, vol. 7, p. 515-21, 2001.
Takeuchi et al., Clinical Cancer Res, vol. 3, p. 2229-2236, 1997.
Arber, et al., “Abnormalities in the Expression of Cell Cycle-Related Proteins in Tumors of the Small Bowel”,Cancer Epidemiology, Biomarkers and Prevention, 8: 1101-05 (1999).
Matthew, et al., “Alterations in Cyclin D1 Expression in Esophageal Squamous Cell Carcinoma in the Indian Population”,J. Cancer Res and Clin Oncol, 127: 251-57 (2001).
Serrano, et al., “A New Regulatory Motif in Cell-Cycle Control Causing Specific Inhibition of Cyclin D/CDK4”,Nature, 366: 704-07 (1993).
Nakao et al., “Induction of p16 During Immortalization HPV 16 and 18 and Not During Malignant Transformation”British J of Cancer 75(10):1410-1416, 1997.
O'Nions, et al., “p73 Is Over-Expressed In Vulval Cancer Principally As The Δ2 Isoform”British J. Cancer 85(10):1551-1556 (Nov. 2001).
Sano, et al., “Overexpression Of P16 and P14ARF Is Associated With Human Papillomavirus Infection In Cervical Squamous Cell Carcinoma And Dysplasia”Pathology Int. 52:375-383 (May 2002).
Sano et al., “Expression Status of p16 Protein Is Associated With Human Papillomavirus Oncogenic Potential In Cervical and Genital lesions”American J. Pathology 153(6):1741,1998.
Sherr, “The Ink4a/Arf Network In Tumor Suppression”Nature Reviews Mol. Cell Bio 2:731-737, (2001).
Martin Peter
Mengel Michael
Ridder Rüdiger
von Wasielewski Reinhard
Foley Shannon
Howrey LLP
Kung Viola T.
MTM Laboratories AG
Yao Lei
LandOfFree
Method for monitoring and prognosis of disease course of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for monitoring and prognosis of disease course of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for monitoring and prognosis of disease course of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3914382