Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-02-28
2006-02-28
Turner, Sharon (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C435S352000, C435S353000, C435S354000, C435S366000, C435S375000, C530S350000
Reexamination Certificate
active
07005411
ABSTRACT:
The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated inversely with the modulation of the effective amount of the Comm polypeptide in contact with the cell. In a particular embodiment, the Comm polypeptide is provided to the cell by exogenously in a pharmaceutically acceptable composition. In another aspect, the invention provides methods of screening for agents which modulate Robo-Comm interactions. These methods generally involve forming a mixture of a Robo-expressing cell, a Comm polypeptide and a candidate agent, and determining the effect of the agent on the amount of Robo expressed by the cell.
REFERENCES:
Tear et al., Neuron 16(3):501-514, 1996.
Seeger et al., Neuron 10(3):409-26, 1993.
Oyesiku et al., J. Comp. Neurol., 364(1):68-77, 1996.
Reinoso et al., J. Neurosci. Res., 43(4):439-53, 1996.
Skolnick et al., Trends in Biotech., 18(1):34-39, 2000.
WO 95 13367 A (Univ California; Univ Columbia (US)) May 18, 1995; see claims 1-10.
Goodman Corey S.
Kidd Thomas
Mitchell Kevin J.
Russell Claire
Tear Guy
Osman Richard Aron
Regents of the University of California
Turner Sharon
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