Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1995-10-10
1998-10-20
Witz, Jean C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
4353723, 435335, 4241431, C12N 506, C12N 508, C12N 500, A61K 39395
Patent
active
058245510
ABSTRACT:
The invention is based upon the newly recognized ability of .beta. chemokines to inhibit cell apoptosis. In particular, apoptosis of T cells is described. The known .beta. chemokines I-309 and TCA-3 are examples of the .beta. chemokines which inhibit apoptosis. One aspect of the invention is the use of these molecules to inhibit apoptosis. A second aspect of the invention is the use of .beta. chemokine inhibitors or antagonists to provoke apoptosis.
REFERENCES:
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Damme Jo Van
Houssiau Frederic
Proost Paul
Renauld Jean-Christophe
Hanley Susan
Ludwig Institute for Cancer Research
Witz Jean C.
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