Method for modifying the toxicity of DNA reactive cross-linking

Details Method for modifying the toxicity of DNA reactive cross-linking Method for modifying the toxicity of DNA reactive cross-linking

1987-06-26

1991-09-24

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, C12N 500

Patent

active

050513630

ABSTRACT:
The cytotoxicity of DNA reactive cross-linking agents can be modified or reversed by exposing cells exposed to such agents to specific endocytotically absorbed materials. These materials should be capable of interfering with the cross-linking of the DNA. For example, electrophillic materials such as serum proteins, are useful for this purpose.

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