Method for modifying the cell, tissue or host tropism of microor

Details Method for modifying the cell, tissue or host tropism of microor Method for modifying the cell, tissue or host tropism of microor

1994-12-22

1996-12-03

Ziska, Suzanne E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424815, 4351721, 4351723, 435236, 536 231, 536 241, C12N 1500, C12N 704, A61K 3912, C07H 2104

Patent

active

055805647

ABSTRACT:
The invention relates to a microorganism having a modified cell, tissue or host tropism whereby at least one gene of the microorganism, preferably an essential gene, is brought under the control of a nucleotide sequence specific for the cell, the tissue or the host. The specific nucleotide sequence can be a promoter sequence and/or enhancer sequence, which can be inducible. The invention is also directed at the use of such a recombinant microorganism for the provision of protection against the corresponding natural microorganism.

REFERENCES:
patent: Re33772 (1991-12-01), Berns et al.
patent: 5047237 (1991-09-01), Cochran et al.
A. Gielkens et al., "Genome Differences among Field Isolates and Vaccine Strains of Pseudorabies Virus," J. gen. Virol, 66:69-82, (1985). GB only pp. 69 & 70 considered since only pp. 69 & 70 were submitted.
Virus Infections of Vertebrates 2, Elsevier Science Publishers B.V., p. 39, "Pseudorabies Virus (Aujeszky's Disease)".
J. T. van Oirschot et al., "Some Characteristics of four attenuated vaccine virus strains and a virulent strain of Aujesky's disease virus," The Veterinary Quarterly, vol. 6, No. 4, pp. 225-229, 1984.
Veterinary Virology, Academic Press, Inc., pp. 353-357, 1987.

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