Method for modifying, diagnosing and screening for IGF-I sensiti

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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514 3, 514 2, 435 29, G01N 3250

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057364001

ABSTRACT:
A method of chronic modification of cell barrier properties by exposing a cell to a modification-effective amount of IGF-I for at least about 7 days wherein the modification effective amount is between about 50 .mu.g/kg and less than about 500 .mu.g/kg is disclosed. Further disclosed is a method of chronic amelioration or reversal of insulin resistance as well as a method of diagnosing and screening for rhIGF-I sensitive cell barrier properties.

REFERENCES:
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Usala, Anton-Lewis, et al., "Brief Rpt.: Treatment of Insulin-Resistant Diabetic . . . "; NEJM, vol. 327, No. 12, pp. 853-857, 1992.
Zenobi, Peter, et al., "Insulin-like Growth Factor -I . . . "; J. Clin. Invest., vol. 90, pp. 2234-2241, Dec. 1992.
Zenobi, Peter, et al., "Effects of IGF-I on Glucose Tolerance . . . " J. Clin. Invest., vol. 89, pp. 1908-1913, Jun. 1992.
Schalch, Don S., et al., "Short-term metabolic effects of rhIGF-I . . . " Modern Concepts of IGF, pp. 705-713, 1991.
Elahi, D., et al., "Hemodynamic and Metabolic Responses to Human IGFI . . . "; Modern Concepts of IGF, p. 219-224, 1991.
Quin, John et al., "Acute Response to IGF-I in a Patient . . . ", Correspondence Section; NEJM, vol. 323, No. 20, pp. 1425-1426, 1990.

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