Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2008-05-13
2008-05-13
Ton, Thaian N. (Department: 1632)
Chemistry: molecular biology and microbiology
Vector, per se
C435S346000, C435S325000, C435S091400, C536S023100
Reexamination Certificate
active
09763362
ABSTRACT:
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of:(a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell;(b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and(c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
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Hanaoka Kazunori
Ishida Isao
Kuroiwa Yoshimi
Oshimura Mitsuo
Tomizuka Kazuma
Foley & Lardner LLP
Kirin Pharma Kabushiki Kaisha
Ton Thai-an N.
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