Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2004-03-30
2008-09-16
Romeo, David (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C530S326000, C435S069700, C514S002600
Reexamination Certificate
active
07425540
ABSTRACT:
The present invention provides a method for modifying the activity of NMDA (N-methyl-D-aspartate)receptors in cells by inhibition of the interaction of the unique domain of the tyrosine kinase Src enzyme and the NMDA receptor complex.
REFERENCES:
patent: 4994446 (1991-02-01), Sokolovsky
patent: 5523323 (1996-06-01), Maccecchini
patent: 5888996 (1999-03-01), Farb
patent: 5914403 (1999-06-01), Nichols
patent: 6653354 (2003-11-01), Franks
patent: 6703489 (2004-03-01), Ish-Horowicz
patent: 2002/0077322 (2002-06-01), Ayoub
patent: 2002/0123510 (2002-09-01), Chenard
patent: 2003/0050243 (2003-03-01), Tymianski
patent: 1 244 638 (2004-05-01), None
Gingrich et al (2001) Society for Neuroscience Abstract. Program # 33.14, poster location C-65. Abstract, p. 1 of 1.
Schwarze et al. (1999). Nature. 285, 1569-1572.
M. Ingman et al, “NADH dehydrogenase subunit 2 [Homo sapiens]”, Genebank, Accession No. AAK17260 (Aug. 22, 2003).
S. Lei et al, “Platelet-derived growth factor receptor-induced feed-forward inhibition of excitatory transmission between hippocampal pyramidal neurons”, J. Biol. Chem., 274(43):30617-30623 (Oct. 1999).
M. Chen et al, “Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor submit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia”, Neuroscience Letters, 339:29-32 (Mar. 2003).
M. Aarts et al, “Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions”, Science, 298:846-850 (Oct. 2002).
W-Y. Lu et al, “G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors”, Nature Neuroscience, 2(4):331-338 (Apr. 1999).
X-M. Yu et al, “Gain control of NMDA-receptor currents by intracellular sodium”, Nature, 396:469-473 (Dec. 1998).
K. Pelkey et al, “Tyrosine phosphatase Step is a tonic brake on induction of long-term potentiation”, Neuron, 34:127-138 (Mar. 2002).
Y-Q. Huang et al, “CAKB/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus”, Neuron, 29:485-496 (Feb. 2001).
Y. Lu et al, “Src activation in the induction of long-term potentiation in CA1 hippocampal neurons”, Science, 279:1363-1367 (Feb. 1998).
X-M. Yu et al, “NMDA channel regulation by channel-associated protein tyrosine kinase Src”, Science, 275:674-677 (Jan. 1997).
G. Shepherd et al, “Three-dimensional structure and composition of CA3-CA1 axons in rat hippocampal slices: implications for presynaptic connectivity and compartmentalization”, The Journal of Neuroscience, 18(20):8300-8310 (Oct. 1998).
J. Walker, “The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains”, Quarterly Reviews of Biophysics, 25(3):253-324 (1992).
D. Ali et al, “NMDA receptor regulation by Src kinase signaling in excitatory synaptic transmission and plasticity”, Current Opinion in Neurobiology, 11:336-342 (2001).
M. Brown et al, “Regulation, substrates and functions of src”, Biochimica et Biophysica Acta, 1287:121-149 (1996).
J. Coyle et al, “Oxidative stress, glutamate, and neurodegenerative disorders”, Science, 262:689-695 (Oct. 1993).
S. Davis et al, “Selfotel in acute ischemic stroke possible neurotoxic effects of an NMDA antagonist”, Stroke, 31:347-354 (Feb. 2000).
V. Dawson et al, “Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures”, Proc. Natl. Acad. Sci. USA, 88:6368-6371 (Jul. 1991).
R. Dingledine et al, “The glutamate receptor ion channels”, Pharmacological Reviews, 51(1):7-61 (1999).
I. Fearnley et al, “Conservation of sequences of subunits of mitochondrial complex I and their relationships with other proteins”, Biochimica et Biophysica Acta, 1140:105-134 (1992).
A. Fix et al, “Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex”, Experimental Neurology, 123:204-215 (1993).
D. Friel et al, “Mitochondria as regulators of stimulus-evoked calcium signals in neurons”, Cell Calcium, 28(5/6):307-316 (2000).
J. Henderson et al, “The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function”, Neuron, 32:1041-1056 (Dec. 2001).
N. Ibrahim et al, “Regulation of mitochondrial protein synthesis at the polyribosomal level”, The Journal of Biological Chemistry, 251(1):108-115 (Jan. 1976).
E. Kramar et al, “Integrins modulate fast excitatory transmission at hippocampal synapses”, The Journal of Biological Chemistry, 278(12):10722-10730 (Mar. 2003).
B. Lin et al, “Integrins regulate NMDA receptor-mediated synaptic currents”, J. Neurophysiol., 89:2874-2878 (May 2003).
J. MacDonald et al, “Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture”, Journal of Physiology, 414:17-34 (1989).
N. Sans et al, “A developmental change in NMDA receptor-associated proteins at hippocampal synapses”, Journal of Neuroscience, 20(3):1260-1271 (Feb. 2000).
B. Soltys et al, Trends in Biochemical Science, 24:174-177 (1999).
M. Takasu et al, “Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors”, Science, 295:491-495 (Jan. 2002).
K. Wu et al, “The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide”, Proc. Natl. Acad. Sci. USA, 94:13273-13278 (Nov. 1997).
Y. Wang et al, “Regulation of NMDA receptors by tyrosine kinases and phosphatases”, Nature, 369:233-235 (May 1994).
B. Soltys et al, “Mitochondrial proteins at unexpected cellular locations: export of proteins from mitochondria from an evolutionary perspective”, International Review of Cytology, 194:133-196 (1999).
C. Ikonomidou et al, “Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?”, The Lancet Neurology, 1:383-386 (Oct. 2002).
E. Kandel, “The molecular biology of memory storage: a dialogue between genes and synapses”, Science, 294:1030-1038 (Nov. 2001).
M. Kennedy et al, “Biochemical and immunochemical evidence that the ‘major postsynaptic density protein’ is a subunit of a calmodulin-dependent protein kinase”, Proc. Natl. Acad. Sci. USA, 80(23):7357-7361 (Dec. 1983).
X. Liu et al, “Potentiation of formalin-evoked adenosine release by an adenosine kinase inhibitor and an adenosine deaminase inhibitor in the rat hind paw: a microdialysis study”, European Journal of Pharmacology, 408:143-152 (2000).
L. Luttrell et al, “The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals”, Journal of Cell Science, 115:455-465 (2002).
R. Malenka et al, “Long-term potentiation—a decade of progress?”, Science, 285:1870-1874 (Sep. 1999).
P. Mariottini et al, “Identification of the polypeptides encoded in the unassigned reading frames 2, 4, 4L, and 5 of human mitochondrial DNA”, Proc. Natl. Acad. Sci. USA, 83:1563-1567 (Mar. 1986).
M. Marusich et al, “Expression of mtDNA and nDNA encoded respiratory chain proteins in chemically and genetically-derived Rho0 human fibroblasts:a comparison of subunit proteins in normal fibroblasts treated with ethidium bromide and fibroblasts from a patient with mtDNA depletion syndrome”, Biochimica et Biophysica Acta, 1362:145-159 (1997).
G. Morris et al, “Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: reuslts of two Phase III clinical trials”, J. Neurosurg., 91:737-743 (1999).
M. Mattson, “Apoptosis in neurodegenerative disorders
Gingrich Jeffrey R.
Salter Michael W.
McHale & Slavin P.A.
Romeo David
Standley Steven H
The Hospital for Sick Children
LandOfFree
Method for modification of NMDA receptors through inhibition... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for modification of NMDA receptors through inhibition..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for modification of NMDA receptors through inhibition... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3992113