Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-24
1997-11-25
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514648, A61K 31445, A61K 31135
Patent
active
056913559
ABSTRACT:
The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## wherein either R.sup.4 is H or a lower alkyl radical and R.sup.5 is a lower alkyl radical, or R.sup.4 and R.sup.5 are joined together with the adjacent nitrogen atom to form a heterocyclic radical;
REFERENCES:
patent: 4133814 (1979-01-01), Jones et al.
patent: 4380635 (1983-04-01), Peters
patent: 4418068 (1983-11-01), Jones
patent: 4623660 (1986-11-01), Richardson
patent: 4656187 (1987-04-01), Black et al .
Draper, M.W., et al., "Effects of Raloxifene (LY139481 HC1) on Biochemical Markers of Bone and Lipid Metabolism in Healthy Postmenopausal Women", Hong Kong, Fourth Int'l Symp. on Osteoporosis, Mar. 29, 1993.
Fisher, B., et al., JNCI, 86(7):527-537 (1994).
Malfetano, J.H., Gynecol. Oncol., 37:82-84 (1990).
Kirkland, J.L., et al., Molecular PHarmacology, 43:709-714 (1993).
Wakeling, A.E., et al., J. Steroid Biochem., 20(1):111-120.
Jordan, V.C., et al., Ann. N.Y. Acad. Sci. 622:439-446 (1991).
Gottardis, et al., Cancer Research, 50, 3189-3192 (1990).
Bryant Henry U.
Fuchs-Young Robin S.
Boone David E.
Eli Lilly and Company
Goldberg Jerome D.
Sales James J.
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