Fluid handling – Processes
Reexamination Certificate
2005-06-21
2005-06-21
Hepperle, Stephen M. (Department: 3753)
Fluid handling
Processes
C137S896000, C366S341000, C366S348000
Reexamination Certificate
active
06907895
ABSTRACT:
Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
REFERENCES:
patent: 3226036 (1965-12-01), Grahn
patent: 3788557 (1974-01-01), Breunsbach
patent: 5900130 (1999-05-01), Benvegnu et al.
Armand Ajdari,Transverse electrokinetic and microfluidic effects in micropatterned channels: Lubrication analysis for slah geometrics, The American Physical Society, Physical Review E, vol. 65, 016301.
Abraham D. Stroock, Stephan K. W. Dertinger, Armand Ajdari, Igor Mezić, Howard A. Stone, George M. Whitesides,Chaotic Mixer for MicrochannelsScience, vol. 295, Jan. 25, 2002, pp. 647-651.
Johnson Timothy J.
Locascio Laurie E.
Ross David J.
Cochran Freund & Young LLC
Hepperle Stephen M.
The United States of America as represented by the Secretary of
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