Method for microbiologically hydroxylating biphenyl and terpheny

Details Method for microbiologically hydroxylating biphenyl and terpheny Method for microbiologically hydroxylating biphenyl and terpheny

1990-12-24

1991-09-17

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing at least three carbocyclic rings

435128, 435130, 435135, 435147, 435156, 435254, 435913, C12P 1500, C12P 1300, C12P 1100, C12R 166

Patent

active

050494961

ABSTRACT:
A. parasiticus is employed to hydroxylate biphenyls or terphenyls. The hydroxylation reaction is enhanced by gradually adding a carbon source to the culture medium-reaction medium, preferably in an amount to maintain the ammonium level below 300 ppm. during the bioconversion phase. Employment of a mutant strain of A. parasiticus which was isolated following ultraviolet light mutagenesis to reduce its tendency to produce aflatoxins is preferred.

REFERENCES:
patent: 4431736 (1984-02-01), Romesser
patent: 4981793 (1991-01-01), Johnson et al.
Salvo et al., Biotechnol. Prog., 6, 193-197 (1990).
Cox et al., Biotechnol. Bioeng., 1985, 27, 1395-1402.

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