Chemistry: analytical and immunological testing – Oxygen containing – Carbonyl – ether – aldehyde or ketone containing
Reexamination Certificate
2007-11-05
2011-11-29
Soderquist, Arlen (Department: 1777)
Chemistry: analytical and immunological testing
Oxygen containing
Carbonyl, ether, aldehyde or ketone containing
C436S043000, C436S052000, C436S127000, C436S128000, C436S161000, C436S177000, C436S178000
Reexamination Certificate
active
08067242
ABSTRACT:
The present invention relates to the determination of the presence of methylmalonic acid in biologic samples including the steps of methylmalonic extraction from the sample; derivatization of methylmalonic acid and use of mass spectrometry with negative mode atmospheric pressure chemical ionization to determine the presence of methymalonic acid throughthe formation of an ion of mass to charge ratio (m/z) 477. An additional objective of the present invention concerns diagnosis kits for determination of presence and quantification of methylmalonic acid based on the method mentioned before.
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Kok Fernando
Melechco Carvalho Valdemir
Goldberg Joshua B.
Harkins Tanya E.
Soderquist Arlen
The Nath Law Group
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