Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Patent
1996-03-15
1999-04-06
Alexander, Lyle A.
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
422 52, 436 63, 436 86, 436106, 436107, 436114, 436116, 436117, 436118, 436172, 436175, G01N 3372
Patent
active
058917357
ABSTRACT:
Nitrosyl (FeII) hemoglobin can be detected in biological samples, using a method which involves injections of samples into a photolysis cell, prior to detection of chemiluminescence generated by the reaction between nitric oxide and ozone. This method is useful for monitoring the levels of nitric oxide bioactivity in both normal physiological states, and disease states, such as septic shock, atherosclerosis, thrombosis, hyperhomocysteinemia, pulmonary hypertension, malignancy, infections and central nervous system disorders.
REFERENCES:
patent: 3967933 (1976-07-01), Etess et al.
patent: 3973910 (1976-08-01), Fine
patent: 3996008 (1976-12-01), Fine et al.
patent: 4018562 (1977-04-01), Parks et al.
patent: 4066411 (1978-01-01), Fine et al.
patent: 4193963 (1980-03-01), Bruening et al.
patent: 4236895 (1980-12-01), Stahl
patent: 4301114 (1981-11-01), Rounbehler et al.
patent: 4368262 (1983-01-01), Bucovaz et al.
patent: 4657744 (1987-04-01), Howard
patent: 4822564 (1989-04-01), Howard
patent: 5094815 (1992-03-01), Conboy et al.
patent: 5151369 (1992-09-01), Lewis et al.
patent: 5258311 (1993-11-01), Lewis et al.
patent: 5346599 (1994-09-01), Stamler et al.
patent: 5366900 (1994-11-01), Conboy et al.
patent: 5380824 (1995-01-01), Marschall et al.
patent: 5459076 (1995-10-01), Stamler et al.
Stamler, Jonathan S., et al., "Nitric Oxide Circulates in Mammalian Plasma Primarily as an S-Nitroso Adduct of Serum Albumin," Proc. Natl. Acad. Sci. USA, 89:7674-7677 (1992).
Gaston, Benjamin, et al., "Endogenous Nitrogen Oxides and Bronchodilator S-Nitrosothiols in Human Airways," Proc. Natl. Acad. Sci. USA, 90:10957-10961 (1993).
Sonoda, Masaru et al., "Diazotization Reaction of Nitric Oxide Trapped by Hemoglobin," Life Sciences, 55(11):199-204 (1994).
Murphy, M.E. and Noack, E., "Nitric Oxide Assay Using Hemoglobin Method," Methods in Enzymology, 233:240-249 (1994).
Stamler, J.S. and Feelisch, M., "Preparation and Detection of S-Nitrosothiols," Methods in Nitric Oxide Research, M. Feelisch and J.S. Stamler, eds., John Wiley & Sons, Ltd. (1996).
Saville, B., "A Scheme for the Colorimetric Determination of Microgram Amounts of Thiols," Analyst 83:670-672 (1958).
Alexander Lyle A.
Carrillo S.
Duke University Medical Center
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