Method for measuring muscle mass

Surgery – Truss – Pad

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A61B 5103

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056283288

ABSTRACT:
A method for determining muscle mass in a human subject useful for monitoring athletic conditioning, weight loss programs, nutritional deficiencies, and disease states which cause muscle wasting is provided comprising administration of a bolus dose of a metabolic marker for 3-methylhistidine, the use of a three-compartment model to describe data from blood samples collected periodically thereafter, and calculation of muscle mass as a function of specific values generated by the model.

REFERENCES:
patent: 4144763 (1979-03-01), Vogelman
patent: 4184371 (1980-01-01), Brachet
patent: 4616658 (1986-10-01), Shell et al.
patent: 4699887 (1987-10-01), Abbott et al.
patent: 5105825 (1992-04-01), Dempster
patent: 5209919 (1993-05-01), Turteltaub et al.
Abumrad, N.N. et al., "Use of a Heated Superficial Hand Vein as an Alternative Site for the Measurements of Amino Acid Concentrations and for the Study of Glucose and Alanine Kinetics in Man," Metabolism (1981) 30:936-940.
Bates, P.C. et al., "Myofibrillar protein turnover: synthesis of protein-bound 3-methylhistidine, actin, myosin heavy chain and aldolase in rat skeletal muscle in the fed and starved states," Biochem. J. (1983) 214:593-605.
Berman, M. and Weiss, M.F., SAAM Manual, US Department of HEW Publication No. (NIH) 78-180. US GPO, Washington, D.C. (1978).
Blackburn, G.L. et al., "Nutritional and metabolic assessment of hospitalized patients," J. Parenter. Enteral. Nutr. (1977) 1:11-22.
Brenner, U. et al. (1987), "Der Einfluss des Dunndarms auf den 3-Methylhistidin-staffwechsel des Menschen (The effect of the small intestine on 3-methylhistidine metabolism in the human)", Infusionther. Klin. Ernahr. 14:248-251.
Brenner, U. et al., "The contribution of small gut to the 3-methylhistidine metabolism in the adult rat," Metabolism (1987) 36:416-418.
Carraro, F. (1990), "Effect of exercise and recovery on muscle protein synthesis in human subjects," Am. J. Physiol. 259E470-476.
Cobelli, et al., "Models to interpret kinetic data in stable isotope tracer studies," Am. J. Physiol. (Endrocrinol. Metab.) (1987) 253:E551-E564.
Cobelli, C. and Toffolo, G., "Compartmental versus noncompartmental modeling for two accessible pools," Am. J. Physiol. (Endocrinol. Metab.) 247: R488-R496, 1984.
Goldman, R.F. and Buskirk, E.R., "Body volume measurement by underwater weighing: description of a method", In: Techniques for Measuring Body Composition, J. Brozek (Ed.), Washington, D.C.: Nat'l Academy of Sciences (1961), 78-79.
Goodman, M.N., "Differential effects of acute changes in cell Ca2+ concentration on myofibrillar and non-myofibrillar protein breakdown in the rat extensor digitorum longus muscle in vitro: Assessment by production of tyrosine and N-tau-methylhistidine," Biochem. J. (1987) 241:121-127.
Goodman, M.N. and Gomez, M.D.P., "Decreased myofibrillar proteolysis after refeeding requires dietary protein or amino acids," Am. Physiological Soc. (1987), pp. E52-E58.
Harris, C. I. and G. Milne, "The urinary excretion of Nt-methyl histidine in sheep: an invalid index of muscle protein breakdown," Br.J.Nutr. (1980) 44: 129-140.
Harris, C.I. and Milne, G., "The urinary excretion of N-tau-methyl histidine by cattle: validation as an index of muscle protein breakdown," Br. J. Nutr. (1981) 45:411-422.
Harris, C. I. and G. Milne, "The inadequacy of urinary (N-tau)-methyl histidine excretion in the pig as a measure of muscle protein breakdown," Br.J.Nutr. (1981) 45:423-429.
Harris, C.I. et al., "3-Methylhistidine as a measure of skeletal-muscle protein catabolism in the adult New Zealand white rabbit," Biochem. Soc. Trans. (1977) 5:706-708.
Harris, C.I. and Milne, G., "The identification of the N-methyl histidine-containing dipeptide, balenine, in muscle extracts from various mammals and the chicken," Comp. Biochem. Physiol. (1987) 86B(2):273-279.
Haverberg, L.N. et al., "Nt-Methylhistidine content of mixed proteins in various rat tissues," Biochem. Biophys. Acta (1975) 405:67-71.
Horswill, C.A. et al., "Total-body electrical conductivity (TOBEC): relationship to estimates of muscle mass, fat-free weight, and lean body mass," Am. J. Clin. Nutr. (1989) 49:593-598.
Johnson, P. et al., "3-Methylhistidine in actin and other muscle proteins," Biochem. J. (1967) 105:361-370.
Jones, R.H. et al., "Statistical identification of compartmental models with application to plasma protein kinetics," Comp. Biomed. Res. (1984) 17:277-288.
Link, G.A. (1991), "A comprehensive approach to describing protein turnover in lambs," Ph.D. thesis, Department of Animal Science, Iowa State University.
Lohman, T.G. et al., "Bone mineral measurements and their relation to body density in children, youth and adults," Hum. Biol. (1984) 56:667-679.
Long, C.L. et al., "Metabolism of 3-methylhistidine in man," Metabolism (1975) 24:929-935.
Lowell, B.B. et al., "Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation," Metabolism (1986) 35:1121-1127.
Lowell, B.B. et al., "Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle," Biochem. J. (1986) 234:237-240.
Lukaski, H. C. et al., "Relationship between endogenous 3-methylhistidine excretion and body composition," Am. J. Physiol. (Endocrinol. Metab.)(1981) 240(3):E302-E307.
Lukaski, H.C. and Mendez, J., "Relationship between fat-free weight and urinary 3-methylhistidine excretion in man," Metabolism (1980) 29:758-761.
Mendez, J. et al., "Fat-free mass as a function of maximal oxygen consumption an 24-hour urinary creatinine, and 3-methylhistidine excretion," Am. J. Clin. Nutr. (1984) 39:710-714.
Millward, D.J. et al., "Quantitative importance of non-skeletal-muscle sources of N-tau-methyl-histidine in urine," Biochem. J. (1980) 190:225-228.
Millward, D. J. and P. C. Bates, "3-Methylhistidine turnover in the whole body, and the contribution of skeletal muscle and intestine to urinary 3-methylhistidine excretion in the adult rat," Biochem. J. (1983) 214:607-615.
Nishizawa, M. et al., "Fractional catabolic rates of myosin and actin estimated by urinary excretion of N-methyl histidine: the effect of dietary protein level on catabolic rates under conditions of restricted food intake," Br. J. Nutr. (1977) 37:345-353.
Pencharz, P.B. et al., "The effect of an energy-restricted diet on the protein metabolism of obese adolescents: nitrogen-balance and whole-body nitrogen turnover," Clin. Sci. (1980) 59:13-18.
Rathmacher, J.A., "Comparative evaluation of muscle proteolysis by a compartmental model of 3-methylhistidine," Ames:Ph.D. Thesis, Iowa State University, 1994.
Rathmacher, J.A. et al., "A compartmental model of 3-methylhistidine metabolism in humans," Am. Physiological Soc. (1995), pp. E193-E198.
Rathmacher, J.A. et al., "Estimation of 3-methylhistidine production in swine by compartmental analysis," Ann. Meeting Animal Sci. & International Soc. of Applied Ethology (Aug. 1992) abstract.
Rathmacher, J.A. et al., "Relationship between de novo 3-methylhistidine metabolism and body composition in pigs," J. Anim. Sci (1995).
Rathmacher, J.A. et al., "A compartmental model to measure 3-methylhistidine production in dogs following surgery," J. Nutr. (1994).
Rathmacher, J. et al., "The use of compartmental models of 3-methylhistidine flux to evaluate skeletal muscle protein turnover in implanted steers," J. Anim. Sci. (1993) 71:135 (Abstract).
Rathmacher, J.A. et al., "Technical Note: The use of a compartmental model to estimate the de novo production rate of Nt-methylhistidine in cattle," J. Anim. Sci. (1992) 70:2104-2108.
Rathmacher, J.A. et al., "Measurement of 3-methylhistidine production in lambs by using compartmental-kinetic analysis," Br. J. Nutr. (1992) 69:743-755.
Rathmacher, J.A. et al., "Estimation of 3-methylhistidine production in swine by compartmental analysis," J. Anim. Sci. (1992) Abstract, 70:194.
Rathmacher, J.A., et al., "Gas chromatographic-mass spectrometric analysis of stable isotopes of 3-methylhistidine in biological fluids: application to plasma kinetics in vivo," Biol. Mass Spectrom. (1992) 21:560-566.
Sjolin, J. et al.,

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